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Latest Mprize Winners
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Z Dave Sharp
On October 8, 2009 Dave Sharp, University of Texas, San Antonio was awarded the Special Mprize Lifespan Achievement. This special recognition was for the first pharmaceutical intervention to successfully extend the life of laboratory mice. The study, published in the journal Nature, showed that when aging mice were given the drug rapamycin, they lived longer than other mice. Read more about rapamycin in the news and the event. 
Andrzej Bartke
"...Dwarf mice...lack growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH), (and) live much longer than their normal siblings, and exhibit many symptoms of delayed aging." 
Steven Spindler
"Caloric restriction (CR), the consumption of fewer calories while avoiding malnutrition, is a robust method of decelerating aging and the development of age-related diseases. The effects of CR are conserved in nearly every species tested, perhaps including humans. CR delays the onset and reduces the incidence and severity of age-related diseases, including cancer." |
Competitor Andrzej BartkeWe are working with mutant mice in which reduced release of several hormones from the pituitary or resistance to the actions of one of these hormones are associated with very impressive (approximately 50%) increase in life expectancy. These animals not only live long but are also partially protected from cancer and other age-related diseases and maintain their memory and learning ability into very late life. Our research, together with the findings from other laboratories, suggests that improved responses to insulin may explain the envious characteristics of these mutant mice. We strongly suspect that altered action of insulin in a particular organ or cell type is responsible for the delay of aging in these mice and that these alterations at a particular stage of life may be especially important. Our aim is to find how, where and when must the action of insulin be altered to produce a long-lived individual. Few people not directly involved in gerontological research are fully aware of the exciting developments in the study of aging and what I feel is the very real prospect of devising effective means of postponing age-related disease and functional decline and yes, prolonging life. The Methuselah Mouse Prize captures popular attention, as evidenced by extensive media coverage it already received, and I believe will play a very important role in securing continued public interest in the work on mechanisms and control of aging. 
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