Researchers – LysoSENS is Recruiting in Tempe

The LysoSENS research project is funded by the generous donations of Methuselah Foundation supporters. SENS stands for the Strategies for Engineered Negligible Senescence, a forward-looking research plan aimed at the development of effective therapies to repair age-related cellular damage.

Lyso-SENS is the latest Methuselah Foundation initiative aimed at tackling age-related storage diseases. These diseases, informally also called “junk” diseases, are caused by the accumulation of some pathogenic material in the body. With advancing age our bodies cannot degrade or remove this junk. Examples of candidate age-related storage diseases include

  • Heart disease and stroke – cholesterol and oxidized cholesterol in the artery wall
  • Alzheimer’s disease – Beta-amyloid plaques and neurofibrillary tangles in the brain
  • Age-related macular degeneration – Lipofuscin of the retinal pigment epithelium
  • Diabetes – Extracellular matrix protein crosslinks, due to exposure of the tissue to high sugar levels

    In every case, it is thought that the selective removal of the respective substances would be extremely beneficial, although obviously nobody has directly tested this. Lyso-SENS is an attempt to do just that, in the worst case paving the ground for rethinking what age-related storage diseases are all about, and in the best case providing a cure for them.

  • The first arm of the donor-funded LysoSENS research project is now recruiting:

    At the LysoSENS project here in Tempe, Arizona, we are looking for reinforcements.

    We offer:

  • The opportunity to truly make a difference and bring SENS research forward.
  • Flexible conditions: Your responsibilities will reflect your qualifications. Apply to come for weeks, months or permanently.
  • Cutting edge working environment and a reputable entry on your CV, see
  • Research credits for a degree at Arizona State, if you are pursuing one. If elsewhere, you can probably get this work accredited, too.
  • Enabling financial support, but no competitive salary.

    We want:

  • The motivation to make personal sacrifices in order to help with curing aging.
  • Experience in molecular biology, specifically at least some of the following would be advantageous:
    • Culture of microorganisms

    • Molecular cloning
    • Mutagenesis
    • Genetic engineering
    • Bioinformatics
    • Synthetic organic chemistry
    • Analytic organic chemistry (HPLC, MS, NMR, ect.)
    • Social and leadership skills

    Before the Methuselah Foundation will see more massive philanthropic donations, it needs to show organizational success in funding and supervision of SENS research. Since the SENS challenge got the gerontologists talking, this seems to be pretty much the only remaining limiting factor. If you think so too, then let’s do it! If you are interested, contact the Foundation at

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