The hardworking technology volunteers here at the Methuselah Foundation recently upgraded the donation process to better organize group-funded memberships of The Three Hundred. Appropriately, given their vocal support of longevity research and the Mprize, the first group to try the waters are the transhumanists of the Betterhumans community. Parish Mozdzierz made the first donation for the group: welcome aboard!

Matt Day is the other new member of The Three Hundred this week, demonstrating a committment to help bring us into the age of real, actual, working anti-aging medicine. Thank you for helping to grow the Mprize for longevity research and enhance its effects upon the course of rejuvenation science!

The Methuselah Mouse Prize (MPrize), is the premiere effort of the Methuselah Foundation and is being offered to the scientific research team who develops the longest living Mus musculus, the breed of mouse most commonly used in scientific research. Developing interventions which work in mice is a critical precursor to the development of human anti-aging techniques, for once it is demonstrated that aging in mice can be effectively delayed or reversed, popular attitudes towards aging as ‘inevitable’ will no longer be possible. When aging in mice is shown to be ‘treatable’ the funding necessary for a full-line assault on the aging process will be made available. This is the true power of the Methuselah Mouse Prize, to demonstrate a proof of principle, and give hope to the world that decline in function and age-related disease are no longer guarantees, for us, or for future generations, if we work together now.

Michael presents the results of his examination of the blogosphere over the past week; odds and ends of interest that may have escaped your notice.

http://www.siggibecker.de/blog/archives/2007/02/begriffe-des-21-jahrhunderts/
… Begriffe des 21. Jahrhunderts Verwandte Kategorien: …was wyrd Futuristik Beschleunigung Soziologie Prä-Singularität Weltzustand um 15:45 Gerade weil Zukunft mit Begriffen und Bildern in Köpfen beginnt deren Durchblutung nicht von virtuellen oder realen Schlipsen behindert wird, ist es wichtig den mentalen Werkzeugkasten ständig zu putzen …
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http://futuresheet.com/2007/02/16/if-youre-alive-in-20-years-you-may-be-able-to-live-forever/
…So for humans to extend life we must do two things: first, eliminate the toxins in our environment that make short telomeres a “good thing” while finding a dietary or pharmaceutical method for increasing and preserving the length of our cells’ telomeres….
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http://futuresheet.com/2007/02/14/possible-anti-aging-drug-created/
… New anti-aging drug possible February 14th, 2007 by futuresheet Scientists have discovered a new method of enhancing the activity of a protein that can dramatically extend lifespan, opening up the possibibility of a new “anti-aging” drug. Researchers at the Wistar Institute discovered that a molecule called nicotinamide, a component of vitamin …
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http://infidel753.blogspot.com/2007/02/some-thoughts-on-uploading.html
… The topic of uploading human minds into computers has confronted me in a number of contexts recently. Here are a few related ideas I have been thinking about. Most people familiar with transhumanism will already have their own views on these matters, but this posting may be of interest to those who are new to the subject. What makes me “me”? …
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http://sanityforsale.wordpress.com/2007/02/04/time-lifetime/
… Time – Lifetime February 4th, 2007 Why is our time limited? And does it have to be? Could our age-old dream of immortality ever be possible? In episode two, Michio Kaku explores these questions and meets some of the key people involved in the cutting-edge research into aging. He travels to the amazing Methuselah tree, which is almost 5000 …
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http://begoworld.blogspot.com/2007/02/i-wanna-live-forever-um-no-not-really.html
… Every once in a while I run across a crackpot in the news that intrigues me, certainly for his element of crackpotness (is that even a word?) but also because someone somewhere gave him enough credibility to go and publish an article about said crackpot. Today’s crackpot is Aubrey de Grey. This kook is working on a plan to break down the aging …
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http://longevity-science.blogspot.com/2007/02/sens-3.html
… Scientific Program of the upcoming third conference “Strategies for Engineered Negligible Senescence” (SENS), Cambridge, England, September, 2007. Greetings, I am pleased to get an e-mail message from the organizer of the third Strategies for Engineered Negligible Senescence (SENS) conference, Dr. Aubrey de Grey, which in fact represents a …
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http://rustle.blogsome.com/2007/02/08/311/
… [ adg] i just watched a channel 4 programme called “do you want to live forever”, about Aubrey de Grey, he who believes that humans are able to live almost indefinitely. There wasn’t much science on offer, but plenty of argument from scientists. Having read “sex, power, & suicide”, as mentioned previously, i did notice that one of his 7 basic …This being that Aubrey wants to transfer the DNA from mitochodria to the nucleus, thus better protecting it in a histone layer (something that mitochondria lack). However, the way in which mitochodira regulate energy output seems to require this seperation. such things were not addressed in this show, and i’d be interested to hear what he would have to say….
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http://atomicrazor.blogs.com/atomic_razor/2007/02/questions_for_2.html
… (Sorry for the delay in making this post. 2007 is already more than 10% over. Whatever I might say about my new job, the passage of time has resumed its normal brisk pace.) Will 2007 be the year that transhumanism goes mainstream? A few weeks I’d have “no”. Certainly there is something in the air. Julian Huxley coined the term in 1957. Ed Regis …
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http://blog.myspace.com/index.cfm?fuseaction=blog.view&friendID=36770146&blogID=230862959
… Human Immortality: A Scientific Reality? If you’re alive in 20 years, you may be able to live forever. by Gary Vey for Viewzone From the moment of birth, we begin the battle against death — against the inevitable. Statistics say that a newborn child can expect to live an average of 76 years. But averages may not be what they use to be. In …
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http://malefactor666.livejournal.com/58251.html
… Howdy all, I received an email today from the treasurer of the Methuselah Foundation (a charity based in the US and UK devoted to raising money for research into anti-aging science). The email read as follows: “Dear all, I have been given your contact details by the Chairman of the US charity that I work for, Dr. Aubrey de Grey. I am the Chief …
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http://mercurialhalo.livejournal.com/4820.html
…In case you didn’t know it folks, some experts on technology are predicting changes in technology that the word “rapid” doesn’t cover. In one person’s words, by 2050 or so, ten years of technological progress won’t be like ten years of today’ technological progress -it will be more like ten thousand. While I think that rate of change might have to wait until 2070 or so, it’s probably going to happen pretty soon in terms of human history…
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http://steve98052.livejournal.com/1342.html
… The story is so confusing I have a hard time summarizing it. As well as I can figure it out, it’s about a doctor (Hugh Jackman) trying to invent a cancer cure for his wife (Rachel Weisz) before she dies. Instead, he discovers what appears to be a cure for aging. Meanwhile, she has written a story about a Spanish queen (also Weisz) who sends her …
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http://blog.myspace.com/index.cfm?fuseaction=blog.view&friendID=135591471&blogID=228316668
… So, I’ve recently been listening to Aubrey De Grey, a British ex-computer scientest turned biologist. He’s had rather a lot of airtime both on TV and radio recently. He’s clearly a brilliant academic thinker and he’s convinced that with enough money and support from the scientific community and the public that he can solve the ‘problem’ of …
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http://blog.myspace.com/index.cfm?fuseaction=blog.view&friendID=25401560&blogID=228585151
… In a previous post, a particular young lady has mentioned “stem cell research”. The government has restricted many sciences that would benefit our modern world. It is true that through the theoretical mastery of stem cell research, they have speculated that even limbs could be regenerated. To induce residual cells of a tissue to regenerate said …
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http://www.amarketplaceofideas.com/book-review-a-singularity-is-near-by-ray-kurzweil-hold-onto-your-arse-here-we-go.htm
… Book Review: A Singularity is Near – By Ray Kurzweil – Hold onto your Arse, Here we go! February 17th, 2007 Ray Kurzweil is a serious inventor / technologist. He’s no Art Bell type with lots of wild claims and no underlying fiber of intellect or work to back it all up. This guy is serious. His book is a hard read with some redundance and …
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http://lostlogic.livejournal.com/133330.html
… Human Immortality: A Scientific Reality? If you’re alive in 20 years, you may be able to live forever. Very interesting article about some of the current research into human mortality / immortality. If this paper is correct and we can be immortal within the next 20 years, we’d better be ready to start colonizing other planets, or we’d better be …
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http://blog.myspace.com/index.cfm?fuseaction=blog.view&friendID=127387156&blogID=222871133
… I heard something that got me thinking…….yes, again……….this guy said something that made a lot of sense…..he said that just because we get to live like a thousand years doesn’t mean we are immortal (unable to die), it simply means that we could get to be a thousand years old………aging would be cured but we will still die from …
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A disclaimer: Please note that the blogs linked to here do not represent any official position or opinions of the Methuselah Foundation, and are presented here for your reading. The blogs we present represent only the opinions of their owners and commentators.

As you might recall, Methuselah Foundation research volunteer John Schloendorn requested soil donations throughout 2006, in order to discover microbes that degrade “junk” molecules inside our bodies – the LysoSENS project. Further encouragement for the donors was provided by a soil contest – $100 for what the investigators deem the “best” submitted samples, i.e. the ones that contained the most biodiversity, and were the most difficult to collect. We were amazed at the level of creativity and organizational talent that our soil donors threw at this problem. We are proud to announce the winners of the contest and their stories.

The science:

7-ketocholesterol builds up in our arteries as we age, and is a major troublemaker in heart disease and stroke. Our bodies are very ineffective at removing 7-ketocholesterol once it is in the artery – but modern medicine and the tools of biotechnology aim to do better. 7-ketocholesterol is one example of a type of intracellular junk, one of the seven deadly types of age-related damage. Chemicals that our bodies cannot degrade or dispose of build up over the years, and interfere in the proper working of our bodies.

The discovery and characterization of microbes degrading 7-ketocholesterol was John’s main objective – if a microbe comes equipped with the tools to degrade this chemical, then perhaps we can copy those tools for use in medical therapies. Last year, John found several microbes capable of degrading 7-ketocholesterol in samples submitted by our soil donors, and is now preparing the publication of these findings.

The winners:

5th place: Alexandra Molitor.
Alex travelled to Ecuador for vacation. While fighting a swarm of bloodthirsty mosquitoes at a hot spring near Quito, she suddenly remembered LysoSENS. Lacking any sampling device, she stuffed its mud between two plastic cups, and mailed the assembly from a post office in the middle of nowhere. When it arrived in Tempe, everything was remarkably still in place. I cultured this samples against A2E at elevated temperature, which rapidly killed the A2E chemically, even in the sterile control. When I tried again at 37 degrees, again no luck.

4th place: Guy Bryant
Guy is a cave diver. He took two samples from an underwater cave in northern Florida. The samples where taken 2,200 feet from the entrance of the cave. In the process of making his way out of the cave, he lost one. We received the surviving sample and three others from a subsequent dive in another cave taken at the entrance sink and at different locations within the cave. I combined them and cultured against A2E in marine mineral medium, but had no luck.

3rd place: J. Lewis tightened his least favorite hiking sandals and went for an extended stroll in the muddiest, blackest swamp he could find in Fiji – getting his feet wet for science halfway across the world. Sealed in a bag folded and tied airtight with a hat-strap, the sandals and their swamp cargo returned to the US. J. Lewis, a Tempe local, brought the boots to Biodesign in person, where I happily scratched their precious cargo off. The samples will become part of our growing metagenomic DNA resources, and have not yet undergone selection.

2nd place: Scott Barton is the General Curator of the Tucson Reid Park Zoo. He donated fecal samples from a large selection of animals from all imaginable phyla and geographical regions. As far as I am aware, Scott is the only person on earth who climbed into a lion’s cage for LysoSENS samples — and lived! We found several slow 7-ketocholesterol degraders in these samples. However, since they could not compare with our Nocardias in terms of degradation speed and ease to work with, we did not pursue them further (yet).

And finally the grand winner: Congratulations, and $100 go to Michael Cooper!
Michael obtained the cooperation of several Kentucky funeral directors. This resulted in a large selection of deep grave samples from different graveyards. We used these to construct our first large (>3 Gbp) metagenomic clone library, which has not yet undergone selection. This experiment will hopefully provide an answer to the question whether graveyard soil is the preferred sample source, as a microbial habitat where our target compounds naturally get degraded. Mike would like to acknowledge the funeral directors Mr. Bernard, Mr. Wilson, and Mr. Hamm.

I have been lax in welcoming our most recent supporters to The Three Hundred, philanthropists of (mostly) modest means, all determined to see science bring an end to the frailty, disease and suffering caused by aging. In my defense, new supporters have been arriving rapidly! A warm welcome to James R. Plante, Mats-Erik Pistol, Richard Leis, Jr. and Arif Akhtar:

I have seen first hand the medical effects of ageing and how it destroys people mentally and physically. There is no logical reason why it cannot be curtailed and this is a truly noble pursuit as it should help to reduce the suffering of countless numbers of people. If we have the potential to stop ageing/death then it would be ethically unsound not to fulfill it.

…

It is time to put money where my hopes are.

…

I pledge, like Justin Bonomo, to donate 5% of my poker winnings to SENS research. Unfrotunately I am not of his standards but still … . I find it hard to use this money for a better cause than SENS research. Even if SENS is flawed, which I doubt, it must be tremendously valuable to get rid of “junk” in the body, as one example.

Thank you all for your generosity in support of Methuselah Foundation initiatives such as the Mprize for longevity research and funding for SENS research.

From the desk of Methuselah Foundation chairman Aubrey de Grey:

I am writing to notify you that registration and abstract submission are now open for the third Strategies for Engineered Negligible Senescence (SENS) conference, to be held at Queens’ College, Cambridge, England on September 6th-10th 2007. The early registration and abstract submission deadlines are both June 15th. All details, including forms for abstract submission and online registration, are at the conference website:

http://www.sens.org/sens3/

The preliminary program already has 48 confirmed speakers, all of them world leaders in their field. As for previous SENS conferences, the emphasis of this meeting is on “applied gerontology” — the design and implementation of biomedical interventions that may, jointly, constitute a comprehensive panel of rejuvenation therapies, sufficient to restore middle-aged or older laboratory animals (and, in due course, humans) to a youthful degree of physiological robustness. The list of sessions and confirmed speakers is as follows:

New pharmaceutical interventions in aging: Patrizia D’Alessio, Laura Dugan, Randy Strong

Immunotherapy against cancer: Zheng Cui, Robert Hawkins, Claudia Gravekamp

Persistent viruses in aging: Ruth Itzhaki, Ed Mocarski, Rita Effros, Arne Akbar

Protecting the brain (genes and delivery): Elizabeth Corder, Pedro Alvarez

Damage to long-lived intracellular molecules: Sataro Goto, Kim Janda, Paola Scaffidi

Non-insertional gene therapy: Nicola Philpott, Michele Calos, Fyodor Urnov

Rescue of mitochondrial mutations: Ian Holt, Marisol Corral-Debrinski, Volkmar Weissig, Samit Adhya

Telomeres and cell senescence: Mary Perry, Gillian Butler-Browne, Lenhard Rudolph, Walter Berger

Non-specific nuclear DNA damage in aging: Jan Vijg, Michael Siciliano, Aubrey de Grey

Deriving autologous embryonic stem cells: Chang-Kyu Lee, Wolfgang Engel, Miodrag Stojkovic

Regeneration of complex structures: Stephen Minger, Chris Mason, David Gardiner

Eliminating beta-amyloid: Ashley Bush, Beka Solomon, Yoh Matsumoto, David Morgan

Repair and turnover of extracellular material: Robin Franklin, Dwight Towler, Cato Laurencin

Long-term goals of biomedical gerontology: Chris Phoenix, Ben Best, Ray Kurzweil

Outreach to key communities: Linda Powers, Michael Rose, Huber Warner, Bernard Siegel

In addition, there will be at least a dozen short talks selected from submitted abstracts, as well as poster sessions each evening. Authors of short talks and posters will, like the invited speakers, be invited to submit a paper summarising their presentation for the proceedings volume, which will be published in the high-impact journal Rejuvenation Research early in 2008.

Please note that registration fees are fully inclusive of accommodation and all meals. Journalists wishing to obtain press passes are asked to contact me by email (aubrey@sens.org).

I hope to welcome you to Cambridge in September!

Cheers, Aubrey

Aubrey de Grey
Organiser, SENS 3
Chairman and Chief Science Officer, Methuselah Foundation
Editor-in-Chief, Rejuvenation Research (impact factor 8.571)

Another installment of Michael’s view of the blogosphere has arrived:

http://coolmel.zaadz.com/blog/2007/1/what_the_bleep_is_transhumanism
… What the Bleep is Transhumanism? My blogging pattern in the last few of days seems to be highlighting my transhumanistic interests. So be it. I’ll make this official. This week is Transhumanist Week, at least on my personal blog. I’ve always been interested in science, technology, parapsychology, ufology, …
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http://www.indianpad.com/story/26013
… Life expectancy is increasing in the developed world. But Cambridge University geneticist Aubrey de Grey believes it will soon extend dramatically to 1,000. Here, he explains why. Ageing is a physical phenomenon happening to our bodies, so at some point in the future, as medicine becomes more and more powerful, we will inevitably be able to …
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http://engineering.curiouscatblog.net/2007/01/22/millennials-in-our-lifetime/
… No I don’t mean the generation Y types born in the 1980s and 1990s I mean 1,000 year old people. I doubt it, but according to Cambridge University geneticist Aubrey de Grey – yes. And his credentials are better than mine, well I guess some of us might see who is right. ‘We will be able to live to 1,000′. Do You Want to Live Forever?: As he …
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http://clipmarks.com/clipmark/10AEE5F8-F204-4344-AE3B-1A4D85C781B7/
… clipped by: skwirlinator clipper’s remarks: Great discussion topic. Aubrey de Grey: “The first person to live to 1,000 might be 60 …
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http://pimm.wordpress.com/2007/01/29/biosingularitys-derya-unutmaz-a-t-cell-expert-on-life-extension/
… Biosingularity’s Derya Unutmaz: a T cell expert on life extension. As many other heavyweight bloggers Derya Unutmaz has an A life and a B life. His A life is focusing on the molecular machinery of T cell activation, differentiation, survival and its explotation by HIV as he is an Associate …
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http://economistsview.typepad.com/economistsview/2007/01/does_getting_ol.html
… Paul Krugman emails, in reference to this post at Brad DeLong’s: Brad, Mark – saw the dismal post on Brad’s blog. I wrote about that way back in 96! Here’s what he wrote: Does Getting Old Cost Society Too Much?, by Paul Krugman, Commentary, NY Times: Back in the early 1980′s, before most of us had ever heard of the Internet, science-fiction …
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http://www.lifestudies.org/weblog/2007/01/john_harris_immortal_ethics_ge.html
.. John Harris’s paper, “Immortal Ethics,” published in Annals of New York Academy of Sciences, 1019, pp. 527-534, (2004), is a short essay on the ethics of life extension. He talks about various points concerning this topic, and his discussion is interesting and thought-provoking. Basically, I don’t like his extremism and …
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http://mikecapone.blogspot.com/2007/01/new-aubrey-de-grey-piece-on-bbc.html
… ‘We will be able to live to 1,000′ …
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http://annajaneclare.livejournal.com/19511.html
… But right there you have one very good reason why clinical immortality would be a very bad idea – the type of people who want to live forever are most likely to be the kind of people who could use a good squishing from the big Monty Pythonesque foot of the inevitable. …
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http://unifiedhealth.blogspot.com/2007/01/would-you-want-to-live-to-be-1000-years.html
… If it were possible to live that long would you choose to? Barring moral implications, environmental implications and personal and religious biases on the topic, would you as an individual, be willing to invest in the fruition of this type of longevity? Here’s a short (too short) lecture by Aubrey de Grey on this topic. Mull it over. …
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http://singularityvideos.com/?p=9
… WPvideo 1.10 Aubrey de Grey news interview with Janet Street-Porter on Bloomberg Encounters Download! British (department of genetics at Cambridge University) scientist Aubrey de Grey, Ph.D., is interviewed by Bloomberg news correspondent Janet Street-Porter. A brief overview on how aging could be curable and extreme life extension …
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http://blog.myspace.com/index.cfm?fuseaction=blog.view&friendID=27203837&blogID=222865680
… University of Cambridge Cambridge geneticist Aubrey de Grey : “The first person to live to 1,000 might be 60 already” Life expectancy is increasing in the developed world. But Cambridge University geneticist Aubrey de Grey believes it will soon extend dramatically to 1,000. …
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http://coolmel.zaadz.com/blog/2007/1/do_you_want_to_live_forever
… Do You Want to Live Forever? Very tricky question. Depends on what we mean by forever. But let’s say forever = 5,000 years. My answer would be: Only if I can change bodies when I get bored with my physical body. Otherwise, it would be boring to be in the same body for hundreds or even thousands of years. It would be more like being sentenced in …
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http://pimm.wordpress.com/2007/02/01/accidental-influentials-meet-life-extension-a-breakthrough-idea-for-2007/
… Most of us believe that the massive spreading of an idea through the channels of society, say, ‘big-scale life extension technology is possible and worth realizing’, depends on highly influential people’s production …
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http://blog.myspace.com/index.cfm?fuseaction=blog.view&friendID=55820122&blogID=225911111
… When I tell people that I plan on living for thousands of years, if not forever, I get a few different reactions depending on their beliefs. The majority of people simply think I’m crazy, but mainly they express concern that it’s not natural, and that they would never want to live forever even if it was possible. …
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http://www.transfigurism.org/news/transhumanism/?p=54
… As I pointed out yesterday, while the concepts of radical life extension are old hat for transhumanists and other healthy life extension advocates, …
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A disclaimer: Please note that the blogs linked to here do not represent any official position or opinions of the Methuselah Foundation, and are presented here for your reading. The blogs we present represent only the opinions of their owners and commentators.

One of the Methuselah Foundation volunteers today noted:

There is quiz show on BBC2 national TV here in the UK called “Weakest Link”. On the Wednesday show one of the questions asked what the purpose of the Methuselah Foundation was. Not only that—-the contestant got the answer right.

How cool is that.

It’s a crude barometer for the effect of the Foundation’s work – such as the Mprize – on public understanding of aging research and the future of longevity, but it is encouraging to hear such reports.

As more people hear and understand the prospects for scientists to develop technologies capable of repairing the damage of aging, more people will step forward to support the necessary research. Broad, rapid progress in longevity medicine depends upon the support of a large constituency who understand that progress is possible, and who wish to see the science move forward.