Friday 19th September
11:00-13:15: Registration
13:15	Aubrey de Grey University of Cambridge Denham Harman University of Nebraska	Welcome and introductory remarks
13:30	Michael West President and CEO, Advanced Cell Technology, Inc., Worcester, MA	Keynote Lecture: Human therapeutic cloning: opportunities and challenges
14:20	Break
Session 1: short talks on brain and heart (Chairs: Tom Prolla and Christiaan Leeuwenburgh)
14:30	Tom Prolla	Age-related impairment of the transcriptional responses to oxidative stress in the mouse heart
14:45	Ruth Itzhaki	The role of viruses and of APOE in dementia
15:00	Emil Toescu	Metabolic substrates of neuronal ageing
15:15	Elizabeth Corder	Gender differences in Alzheimer's disease neuropathology
15:30	Christiaan Leeuwenburgh	Cell signaling and apoptosis in aging
15:45	Coffee
Session 2: "Regenerating poorly autoregenerative tissues (1)" (Chairs: Mark Smith and Richard Aspinall)
a) "Brain"
16:00	Mark Smith Professor, Institute of Pathology, Case Western Reserve University, Cleveland	Alzheimer Disease: causes, consequences, and surprises
16:30	Clive Svendsen Professor, Department of Anatomy and Neurology, Waisman Center, U. Wisconsin-Madison	Combining stem cell and gene therapy for the aging brain
17:00	Roger Nitsch Professor and Director, Division of Psychiatry Research, University of Zurich, Switzerland	Antibodies Against beta-Amyloid Slow Cognitive Decline in Patients with Alzheimer's disease
17:30	Coffee
b) "Other weakly regenerating tissues"
17:50	Nadia Rosenthal Head, EMBL Mouse Biology Programme, EMBL, Monterotondo, Italy	Prometheus' vulture and the promise of stem cells
18:20	Richard Aspinall Lecturer, Department of Immunology, Imperial College School of Medicine, London, UK; Chair, British Society for Research on Ageing	The Magnificent IL-7; an interleukin for rejuvenating the immune system
18:50	Jeremy Brockes Professor of Biochemistry and Molecular Biology, University College, London, UK	New limbs for old - lessons from the newt
19:20	Michael Sefton Professor of Biomedical Engineering, University of Toronto, Canada	Using tissue engineering to produce an unlimited supply of tissues and organs
Inaugural SENS Lecture (Chair: Aubrey de Grey)
19:50	John Harris Sir David Alliance Professor of Bioethics, University of Manchester, UK	Immortal Ethics
20:20	Dinner
21:20	Welcome reception and Poster session 1
Saturday 20th September
7:30	Breakfast
8:30	Mario Capecchi US National Medal of Science awardee, 2001; Distinguished Professor of Biology and Human Genetics, University of Utah	Ellison Medical Foundation Keynote Lecture: Mouse models and human aging
9:20	Break
Session 3: "Regenerating poorly autoregenerative tissues (2)" (Chair: Franklin Rosenfeldt)
a) "Rapidly regenerating tissues"
9:30	Tom Kirkwood Head, Department of Gerontology, University of Newcastle, UK	Intestinal stem cell ageing: role of mitochondrial mutation?
10:00	Gary Van Zant Professor of Medicine, University of Kentucky	Genes affecting stem cells, aging and longevity
10:30	Coffee
b) "Heart"
10:50	Ulf Brunk Professor and Chair, Division of Pathology II, University of Linkoping, Sweden	Aging of cardiac myocytes and mitochondrial turnover
11:20	Salvatore Pepe Head, Cardiac Surgical Research Laboratory, Baker Heart Research Institute, Melbourne	Targeting Age-Related Modification and Dysfunction of Heart Cell Membranes: Engineering Reversal with Omega 3 Fatty Acids and Antioxidants
11:50	Franklin Rosenfeldt Head, Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Melbourne	Quest for Mitochondrial Markers of Impaired Post-Ischaemic Functional Recovery in the Ageing Heart and for Clinical Therapeutic Strategies
12:20	Edward Lakatta Chief, Laboratory of Cardiovascular Science, National Institute on Aging	Intervening on cardiovascular aging in health to beat cardiovascular disease
12:50	Lunch
Session 4: short talks on cell senescence and cancer (Chairs: Rita Effros and Suresh Rattan)
14:00	Rita Effros	T cell replicative senescence: pleiotropic effects on human aging
14:15	Beatrix Grubeck-Loebenstein	The effect of environmental versus genetic influences on immunosenescence
14:30	Pidder Jansen-Duerr	Respiration, coupling and ROS in senescent human fibroblasts
14:45	Suresh Rattan	Molecular mechanisms of anti-ageing hormetic effects of repeated mild heat stress on human cells
15:00	Efstathios Gonos	Longevity and survival factors implicated in human ageing and longevity
15:15	Richard Faragher	Camptothecin sensitivity in Werner's syndrome fibroblasts as assessed by the COMET technique
15:30	Fabrizio d'Adda di Fagagna	Telomere-initiated cellular senescence is a DNA damage checkpoint-mediated response
15:45	Coffee
Session 5: "21st-century anti-cancer therapies" (Chairs: Graham Pawelec and Jerry Shay)
a) "Telomere manipulation"
16:00	Jerry Shay Professor of Cell Biology, U. Texas Southwestern Medical Center	Telomerizing Somatic Cells for Tissue Engineering
16:30	Calvin Harley Chief Scientific Officer, Geron Corporation, Menlo Park	Telomerase and regenerative medicine
17:00	Dominique Broccoli Associate Member, Fox Chase Cancer Center, Philadelphia	Alternative lengthening of telomeres: a telomerase independent route to cellular immortality
17:30	Aubrey de Grey Research Associate, Department of Genetics, University of Cambridge, UK	WILT: an ambitious but truly un-escapable anti-cancer therapy
18:00	Coffee
b) "Other strategies"
18:20	Judith Campisi Head, Department of Cell and Molecular Biology, Lawrence Berkeley National Laboratory	Consequences of cellular senescence and prospects for reversal
18:50	Lawrence Donehower Professor, Molecular Virology & Microbiology, Baylor College of Medicine	Analysis of the Role of p53 in Aging Using Mouse Models
19:20	Jean-Pierre Issa Associate Internist and Associate Professor of Medicine, M.D. Anderson Cancer Center	Epigenetic therapy
19:50	Graham Pawelec Professor of Experimental Immunology, University of Tuebingen Medical School	Prevention of T cell ageing will rejuvenate anti-cancer efficacy
20:20	Dinner
21:20	Poster session 2
Sunday 21st September
7:30	Breakfast
8:30	Bruce Ames US National Medal of Science awardee, 1998; Director, National Institute of Environmental Health Sciences Center, U.C. Berkeley	Ellison Medical Foundation Keynote Lecture: Delaying the mitochondrial decay of aging
9:20	Break
Session 6: "Overcoming chromosomal damage" (Chair: Kelvin Davies)
9:30	Jan Vijg Professor of Physiology, U. Texas Health Science Center at San Antonio	Genomic instability in cancer and aging
10:00	Eric Kmiec Professor of Biological Sciences, University of Delaware; Director of Genomics Research, Delaware Biotechnology Institute	Directing the repair of damaged DNA and genetic mutations in vivo
10:30	Coffee
Session 7: "Overcoming cell-cell signalling dysfunction" (Chair: Brian Clark) Sponsored by Senetek plc
10:50	Nir Barzilai Director, Institute for Aging Research, Albert Einstein College of Medicine	Cellular Nutrient Sensing and Longevity
11:20	Mitchell Harman Director and President, Kronos Longevity Research Institute, Phoenix	What do hormones have to do with aging? What does aging have to do with hormones?
11:50	Geoffrey Goldspink Professor of Anatomy and Developmental Biology, Royal Free Hospital and UC Medical School	Age-related muscle loss and progressive dysfunction in mechano- sensitive growth factor signalling
12:20	Sang Chul Park Director, Aging and Physical Culture Research Institute, Seoul National University, S. Korea	Functional efficiency of senescent cells: replace or restore?
12:50	Lunch
Session 8: short talks on oxidative stress (Chairs: Keshav Singh and Abe Reznick)
14:00	Keshav Singh	Mitochondria as coordinators of aging and cancer
14:15	Abe Reznick	Molecular Mechanisms and Signaling Pathways in Muscle Atrophy in Immobilization and Aging
14:30	Igor Afanas'ev	Formation and damaging effects of superoxide in mitochondria: relevance to mitochondrial aging
14:45	Rui-Ming Liu	Glutathione metabolism during aging and in diseases
15:00	Bertrand Friguet	Evidence and identification of preferential protein targets for age-related modifications in peripheral blood lymphocytes
15:15	Sataro Goto	Regular exercise: A possible anti-oxidative strategy in ageing
15:30	Kenichi Kitani	Interventions in aging and age-associated pathologies by means of nutritional approaches
15:45	Coffee
16:00	Arthur Caplan Emanuel and Robert Hart Professor of Bioethics, University of Pennsylvania; Director, Center for Bioethics, University of Pennsylvania	Keynote Lecture: Mr. Yuck meets the Grim Reaper: why living longer is not such a bad thing
16:50	Break
Session 9: "Overcoming oxidative stress" (Chairs: Nir Barzilai and Jan Vijg)
a) "Overcoming mitochondrial damage"
17:00	Gustavo Barja Titular Professor, Complutense University, Madrid, Spain	Oxygen radicals and aging
17:30	Michael King Associate Professor, Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University	Genetic correction of mitochondrial respiratory chain deficiencies
18:00	Konstantin Khrapko Assistant Professor, Harvard Medical School	What is the age of the age-related mutations in mitochondrial DNA?
18:30	Coffee
b) "Enhancing catabolism of recalcitrant molecules"
18:50	John Archer Senior Research Associate, Department of Genetics, University of Cambridge, UK	The biomedical relevance of microbial catabolic versatility
19:20	Kelvin Davies James E. Birren Chair of Gerontology and Molecular Biology, U. Southern California; President, International Society for Free Radical Research	Decline in proteasome and Lon protease activity with age: transcriptional dysregulation or inhibitor accumulation?
19:50	Robert deGroof Senior Vice President, Scientific Affairs, Alteon Inc., Ramsey, NJ	Remodeling of age- and diabetes-related changes in extracellular matrix
20:20	Dinner
21:20	Poster session 3
Monday 22nd September
7:30	Breakfast
8:30	William Haseltine Chairman and CEO, Human Genome Sciences, Inc., Rockville, MD	Keynote Lecture: Regenerative medicine: Systematic Application of Biotechnology, Bioengineering, Nanotechnology and Information Sciences for the Improvement of Human Health
9:20	Break
Session 10: "Preparing society for a possible second epidemiological transition" (Chair: Tom Kirkwood)
9:30	Aubrey de Grey Research Associate, Department of Genetics, University of Cambridge, UK	Biogerontologists' duty to discuss timescales publicly
9:45	David Gobel President, Methuselah Foundation	The Methuselah Mouse Prize
10:00	Jay Olshansky Professor of Epidemiology, School of Public Health, University of Illinois at Chicago	Obesity, Infectious Diseases, and Forecasts of Human Life Expectancy + The Demographic Impact of Immortality
10:30	Coffee
10:50	Gregory Stock Director, Program on Medicine, Technology and Society, U.C. Los Angeles	The promises and pitfalls of planning for demographic change
11:20	John Davis Assistant Professor Department of Medical Humanities, Brody School of Medicine, Greenville, NC	Collective Suttee: If Not Everyone Can Afford Life-Extension, Does That Mean No One Should Have It?"
11:50	Steven Austad Professor, Department of Biological Sciences, University of Idaho	Social, political, and ethical obstacles to human life extension
12:20	Jerry Lemler Alcor Life Extension Foundation, Scottsdale, AZ	Medical Time Travel as a Bridge to Negligible Senescence
12:35	Open discussion from the floor
12:50	Lunch
Session 11: short talks on demography and slow aging (Chairs: Donna Holmes and Stephen Spindler)
14:00	Dellara Terry	The Delay and/or Escape of Cardiovascular Disease in Centenarian Offspring
14:15	Larry Corder	Pathways to exceptional human longevity: New evidence from the 1982-1999 National Long Term Care Surveys
14:30	Stephen Coles	Human Supercentenarian Epidemiology and the Implications for Longevity
14:45	Leonid Gavrilov	Early-Life Programming of Aging and Longevity: The Idea of High Initial Damage Load (the HIDL Hypothesis)
15:00	Stephen Spindler	Rapid identification of candidate CR mimetics using microarrays
15:15	Donna Holmes	Naturally long-lived animal models for the study of slow aging and longevity
15:30	Eugenio Mocchegiani	Immunomodulation, ageing and successful ageing: role of Metallothionein
15:45	Coffee
Session 12: "Bridging the gap: slowing what we cannot yet prevent or reverse" (Chairs: James Joseph and Li Li Ji)
a) "Nutrition and supplementation"
16:00	James Joseph Chief, Neuroscience Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging	Fruit polyphenols in brain aging: Effects on Signaling, Neurogenesis and Behavior
16:30	Christopher Heward Vice-President of Research and Development, Kronos Centre, Phoenix	The Role of Nutrition in Human Health, Disease, and Aging - A Practical Approach
17:00	Donald Ingram Chief, Behavioral Neuroscience Section, National Institute on Aging	Development of calorie restriction mimetics as a prolongevity strategy
17:30	Richard Cutler Vice President, Longevity Sciences, Kronos Science Laboratories, Phoenix	Non-invasive human oxidative stress profiling and its biomedical application
18:00	IABG Business Meeting
18:30	Coffee
b) "Exercise"
18:50	Li Li Ji Professor of Exercise Physiology and Nutritional Science, University of Wisconsin-Madison	Aging, exercise and photochemicals: promises and pitfalls
19:20	Scott Powers Professor, Department of Exercise and Sport Sciences, University of Florida; Vice-President, American College of Sports Medicine	Mechanism(s) responsible for exercise-induced cardioprotection
19:50	James Tidball Director, Duchenne Muscular Dystrophy Research Center, U.C. Los Angeles	Mechanisms regulating muscle wasting during muscle disuse or aging
20:20	Gala Dinner
Tuesday 23rd September
7:30	Breakfast
9:30	Punting on the Cam
11:30	C O N F E R E N C E   A D J O U R N S
Thank you for your attendance and participation!