No.301 Jiefang South Road, Hexi District, Tianjin 300202, CHINA
Objective: To observe the preventive and therapeutic effects of
antithrombin-III (AT-III) on experimental disseminated intravascular
coagulation (DIC) in rabbits. Methods: Rabbits were at random divided
into the control and AT-III plus lipopolysaccharide (LPS) or AT-III
plus thromboplastin (Tp) groups. Experimental DIC was induced by
injection of LPS or Tp. AT-III was intravenously injected after the
injection of LPS or Tp. 2.5 hours later, blood sample were drawn and
the concentration of fibrinogen, prothrombin time (PT), 3P test,
platelet count, AST and CK was measured. Results: As compared with the
controls, it was found that the platelet count and plasma concentration
of fibrinogen were significantly decreased and the PT time showed no
significant difference, but the positive degree of 3P test was
remarkably decreased and the pathologic changes of the heart, liver,
lung and kindney were slight in the high-dose AT-III group. Conclusion:
AT-III can inhibit the DIC and inflammation response caused by LPS or
Tp.
Key words:
Antithrombin-III; Lipopolysaccharide; Disseminated intravascular coagulation; Throm-boplastin; Rabbit
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