|
|
|
Aubrey de Grey's publications
Aubrey de Grey的文章
Most of the following publications are provided
here as PDFs of preprints; where that has not been possible there are links
to abstracts. Reprints are available on request.
Introductions for the
non-specialist
Overviews of the science
underlying SENS
Social context of SENS,
including within biogerontology
Obviation of mitochondrial
mutations
Removal of lysosomal aggregates
A real cure for cancer
Mitochondrial mutations and
their effects
Other
以下所提供的大部分文章是草稿的PDF文件；如果不能弄到草稿，可以链接以获得摘要。已有定稿，点击请求（request）：
非专家入门知识（Introductions for the
non-specialist）
SENS的基础科学概述（Overviews of the science
underlying SENS）
SENS的社会关系（包括在生物老年学之内）（Social context of SENS,
including within biogerontology）
避免线粒体突变（Obviation of mitochondrial
mutations）
除去溶酶体聚集物（Removal of lysosomal aggregates）
真正治愈癌症（A real cure for cancer）
线粒体突变及其效应（Mitochondrial mutations and their
effects）
其他（Other）
Introductions for the
non-specialist:
非专家入门知识:
de Grey ADNJ. An engineer's approach to the development of real anti-aging
medicine. Science's
SAGE KE 2003; 2003(1):vp1. Also in: The Fountain of Youth: Ethical,
Religious, and Existential Perspectives on a Biomedical Goal (S.G. Post,
ed.), Oxford University Press, 2003, pp. 249-267. PDF
de Grey ADNJ. Escape velocity: why the prospect of extreme human life
extension matters now. PLoS
Biol 2004; 2(6):723-726. PDF
Most of my publications are written for a specialist audience of
biogerontologists, but the ones above are intended for a more general
audience. Start here if you're new to the field, and especially if you aren't
a biologist.
Overviews of the science underlying SENS:
SENS的基础科学概述:
de Grey ADNJ, Ames BN, Anderson JK, Bartke A, Campisi J, Heward CB, McCarter
RJM, Stock G. Time to talk SENS: critiquing the immutability of human aging.
In: Increasing Healthy Life Span: Conventional Measures and Slowing the
Innate Aging Process - Ninth Congress of the International Association of
Biomedical Gerontology (D. Harman, ed.), Annals
NY Acad Sci 2002; 959:452-462. PDF
de Grey ADNJ. An engineer's approach to the development of real anti-aging
medicine. Science's SAGE KE 2003; http://sageke.sciencemag.org/cgi/content/full/sageke;2003/1/vp1
Also in: The Fountain of Youth: Ethical, Religious, and Existential
Perspectives on a Biomedical Goal (S.G. Post, ed.), Oxford University Press,
2004, pp. 249-267. PDF
de Grey ADNJ. Challenging but essential targets for genuine anti-ageing
drugs. Expert
Opinion on Therapeutic Targets 2003; 37(1):1-5. PDF
de Grey ADNJ. UK research on the biology of aging -- the next ten years. Lifespan
2003; 11(1):1-4. PDF
Social context of SENS, including within biogerontology:
SENS的社会关系（包括在生物老年学之内）
de Grey ADNJ. Gerontologists and the media: the dangers of over-pessimism. Biogerontology
2000;1(4):369-370. PDF
de Grey ADNJ, Gavrilov L, Olshansky SJ, Coles LS, Cutler RG, Fossel M, Harman
SM. Antiaging technology and pseudoscience. Science
2002; 296(5568):656. PDF
de Grey ADNJ, Baynes JW, Berd D, Heward CB, Pawelec G, Stock G. Is human
aging still mysterious enough to be left only to scientists? BioEssays
2002; 24(7):667-676. PDF
de Grey ADNJ. Fear of misrepresentation cannot justify silence about
foreseeable life-extension biotechnology. BioEssays
2003; 25(1):94-95. PDF
de Grey ADNJ. The foreseeability of real anti-aging medicine: focusing the
debate. Exp
Gerontol 2003; 38(9):927-934. PDF
de Grey ADNJ. Biogerontologists' duty to discuss timescales publicly. Annals NY Acad Sci
2004; 1019:542-545. PDF
de Grey ADNJ. Escape velocity: why the prospect of extreme human life
extension matters now. PLoS
Biol 2004; 2(6):723-726. PDF
de Grey ADNJ. The war on aging. In: The
Scientific Conquest of Death (B.J. Klein et al., eds.), Libros en Red, 2004,
pp. 17-29. PDF
de Grey ADNJ. Leon Kass: quite substantially right. Rejuvenation
Res 2004; 7(2):89-91. PDF
de Grey ADNJ. Three self-evident life-extension truths. Rejuvenation
Res 2004; 7(3):165-167. PDF
de Grey ADNJ. Aging, childlessness or overpopulation: the future's right to
choose. Rejuvenation
Res 2004; 7(4):237-238. PDF
Obviation of mitochondrial mutations:
避免线粒体突变:
de Grey ADNJ. Are those 13 proteins really unimportable? In: From Symbiosis
to Eukaryotism - Endocytobiology VII (E. Wagner et al., eds.), Geneva
University Press, 1999, pp. 489-502.
de Grey ADNJ. Mitochondrial gene therapy: an arena for the biomedical use of
inteins. Trends
Biotechnol 2000; 18(9):394-399. PDF
de Grey ADNJ. Response to "approaches and limitations to gene therapy
for mitochondrial diseases," Antioxid. Redox Signal. 2001;3:451-460. Antioxid
Redox Signal 2001; 3(6):1153-1155. PDF
de Grey ADNJ. Inter-species therapeutic cloning: the looming problem of
mitochondrial DNA and two possible solutions. Rejuvenation
Res 2004; 7(2): 95.98. PDF
de Grey ADNJ. Forces maintaining organellar genomes: is any as strong as
genetic code disparity or hydrophobicity? BioEssays 2005; 27(4):436-446. PDF
Removal of lysosomal aggregates:
除去溶酶体聚集物:
de Grey ADNJ. Bioremediation meets biomedicine: therapeutic translation of
microbial catabolism to the lysosome. Trends
Biotechnol 2002; 20(11): 452-455. PDF
A real cure for cancer:
真正治愈癌症:
de Grey ADNJ, Campbell
FC, Dokal I, Fairbairn LJ, Graham GJ, Jahoda CAB, Porter ACG. Total deletion
of in vivo telomere elongation capacity: an ambitious but possibly ultimate
cure for all age-related human cancers. Annals NY Acad Sci
2004; 1019:147-170. PDF
Mitochondrial mutations and their effects:
线粒体突变及其效应:
de Grey ADNJ. A proposed
refinement of the mitochondrial free radical theory of aging. BioEssays
1997; 19(2):161-166. PDF
de Grey ADNJ. A mechanism proposed to explain the rise in oxidative stress
during aging. J Anti-Aging Med 1998; 1(1):53-66. PDF
de Grey ADNJ. The
mitochondrial free radical theory of aging. Austin, TX: Landes
Bioscience, 1999, 212pp, hardcover (ISBN 1-57059-564-X).
de Grey ADNJ. The non-correlation between maximum longevity and enzymatic
antioxidant levels among homeotherms; implications for retarding human aging.
J Anti-Aging Med 2000; 3(1):25-36. PDF
de Grey ADNJ. The reductive hotspot hypothesis: an update. Arch
Biochem Biophys 2000; 373(1):295-301. PDF
de Grey ADNJ. The reductive hotspot hypothesis of mammalian aging: membrane
metabolism magnifies mutant mitochondrial mischief. Eur
J Biochem 2002; 269(8):2003-2009. PDF
de Grey ADNJ. Mitochondrial mutations in vertebrate aging. In: Oxidative stress and
aging: advances in basic science, diagnostics, and intervention (R.G.
Cutler and H. Rodriguez, eds.), World Scientific Publishing, 2002, pp. 437-451.
PDF
de Grey ADNJ. Mechanisms underlying the age-related accumulation of mutant
mitochondrial DNA. In: Genetics of mitochondrial diseases (I.J. Holt, ed.),
Oxford University Press, 2003, pp. 247-275. PDF
de Grey ADNJ. Mitochondria in homeotherm aging: will detailed mechanisms
consistent with the evidence now receive attention? Aging
Cell 2004; 3(2):77. PDF
de Grey ADNJ. Mitochondrial mutations in mammalian aging: an over-hasty
about-turn? Rejuvenation
Res 2004; 7(3): 171-174. PDF
de Grey ADNJ. Reactive oxygen species production in the mitochondrial matrix:
implications for the mechanism of mitochondrial mutation accumulation. Rejuvenation
Res 2005; 8(1): 13-17. PDF
Other:
其他:
de Grey ADNJ. Incorporation of transmembrane hydroxide transport into the
chemiosmotic theory. Bioelectrochem
Bioenerg 1999; 49(1-2):43-50. PDF
de Grey ADNJ. Biologists abandon Popper at their peril. BioEssays
2000; 22(2):206-207. PDF
de Grey ADNJ. A proposed mechanism for the lowering of mitochondrial electron
leak by caloric restriction. Mitochondrion
2001; 1(2):129-139. PDF
de Grey ADNJ. UK research on the biology of aging. Exp
Gerontol 2001; 37(1):1-7. PDF
de Grey ADNJ. Response to "telomere shortening with aging in human
liver". J
Gerontol A Biol Sci Med Sci 2001; 56(6):B237-B238. PDF
de Grey ADNJ. HO2: the forgotten radical. DNA
Cell Biol 2002; 21(4):251-257. PDF
de Grey ADNJ. Critique of the demographic evidence for "late-life
non-senescence". Biochem
Soc Trans 2003; 31(2):452-454. PDF
de Grey ADNJ. A proposal for the overall structure of the mammalian plasma
membrane redox system. Protoplasma
2003; 221(1-2):3-9. PDF
de Grey ADNJ. Overzealous maximum-likelihood fitting falsely convicts the
slope heterogeneity hypothesis. Exp
Gerontol 2003; 38(8):921-923. PDF
de Grey ADNJ. Falsifying falsifications: the most critical task of
theoreticians in biology. Medical
Hypotheses 2004; 62(6):1012-1020. PDF
de Grey ADNJ. The unfortunate influence of the weather on the rate of aging:
why human caloric restriction or its emulation may only extend life
expectancy by 2-3 years. Gerontology
2005; 51(2):73-82. PDF
|