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SENS roundtable 1: Biotechnological foreseeability of ENS Roundtable
meeting, Oakland, October 1st 2000 SENS圆桌会议 1：掌控可忽略衰老（ENS）的生物技术学可预测性 圆桌会议，奥克兰，2000年10月1日 文章（Article ）
详细资料／抄本（ Details/Transcript） This meeting
was designed to continue and build upon UCLA's pioneering "roundtable on
aging" convened by Gregory Stock in February, 1999. Like the earlier
meeting, it included only about ten participants and had a roundtable format
with no formal presentations. The major departure from the 1999 meeting was
that the focus was somewhat more narrowly defined, as befits a one-day event. 这次会议原为继续并依赖于加州大学洛杉矶分校先驱“老化的圆桌会议”，召集人为Gregory Stock，曾在1999年2月召开过。与上一次会议一样，参加者仅10人，没有正式报告，为圆桌形式。与1999年会议主要不同点是，这次会议关注焦点被定义得有点儿较狭窄，只适合于1天的活动。 We discussed
an aspect of biogerontology research that has been dangerously neglected during
the recent spate of interest in genome-related breakthroughs: the active
reversal of various aspects of age-related degeneration. This is, more-or-less
by definition, an area that cannot be informed by comparative analyses between
organisms with different rates of aging, which is the focus of microarray and
related studies. We do not belittle the value of comparative work, but we feel
that far more attention needs to be drawn to ongoing research with the
potential to influence human life histories more dramatically than anything
based purely on emulating other organisms. 我们讨论了生物老年学研究的一个方面，在兴致勃勃的与基因组有关突破的今天，它被危险地忽视了。它就是关龄退行性变化各方面的主动逆转。按定义，这好呆是一个领域，它不可能被衰老速率不同的有机体之间的比较分析所告知（那样的比较分析就是微阵列及相关研究的焦点）。我们并不小看比较工作的价值，但是，我们感到，多得多的注意力需要被动员到正在进行的影响人类生命史潜力的研究，它比一味模仿其它有机体的任何东西要有戏剧性得多。 The term
"negligible senescence", defined in 1990 by Finch, describes the life
history of organisms whose risk of death does not measurably rise as they get
older, but remains the same as when they reached adulthood. Thus,
"engineered negligible senescence" means restoring and maintaining,
by biotechnological intervention, the health (and consequent resistance to
life-threatening diseases) that we possessed in early adulthood. “可忽略衰老”一词，是由Finch在1990年定义的，该定义描述了有机体如下生命史：当有机体老了时死亡风险并不可测地升高，而仍然相同于他们达到成年时的状况。因此，“掌控可忽略的衰老”意味着借生物技术干预来恢复和维持我们刚成年时所具有的那种健康（其结果是产生对威胁生命的疾病的抵抗力）。
We regard
engineered negligible senescence as the true objective of biogerontology
research. This is in contrast to the view of many gerontologists, who prefer to
stress "successful aging" as their goal. "Successful aging"
means extending healthy life (healthspan) so that the period of ill health at
the end of life (frailty-span) is very short, but without substantially
increasing maximum total lifespan, since they consider that unrealistic. Our
view is that not only is extending maximum lifespan realistic, it is the only realistic way to shorten frailty-span
much beyond present levels, because it entails extending healthspan (and thus
postponing frailty) indefinitely. 我们把掌控可忽略衰老作为生物老年学研究的真正目标。这与很多老年学家的观点不同，后者喜欢强调“成功的衰老”是他们的目标。“成功的衰老”意思是扩展健康的寿命（健寿），使得生命后期的不健康期（虚弱寿命）非常短，但在本质上不增加最高总寿命，因为他们认为那是不切合实际的。我们的观点是，不仅扩展最高寿命是切实可行的，而且它是缩短虚弱寿命的唯一切实可行的途径（虚弱寿命比现在要短得多），因为它需要无限地扩展健寿（这样就延缓了虚弱期）。
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