Methods: After IRB and government approval, adult autologous stem cell therapy was performed in patients with coronary artery disease and an ejection fraction of <35% who are going to have primary OPCAB. The patients were prospectively randomized before operative therapy was performed. Serum BNP levels were evaluated at one, three, and six months after therapy.
Results: There were fifty patients enrolled. In the study group, 25 patients had successful stem cells therapy into ischemic myocardium. The other 25 patients in the control group only had OPCAB. There were no perioperative arrhythmias, neurological or ischemic myocardial events in either group. The preoperative BNP levels were 962 vs 997 in control vs study group. At 6 months the BNP levels had dropped to 335 vs 693 in study vs control group.
Conclusions: Stem cell therapy results in a significant improvement in
congestive heart failure as demonstrated by decreasing serum BNP
levels. Stem cell therapy is a very promising treatment for ischemic
cardiomyopathy.
Key words:
Stem Cell Heart Failure Adult
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