Mice with improved systems for cellular quality control: super-p53 and super-p16/ARF mice
M. Serrano, I. Garcia-Cao, M. Garcia-Cao, A. Matheu, M.A. Blasco
Spanish National Cancer Center (CNIO), Madrid 28029, SPAIN
We are interested in testing the effects of increasing the gene dosage
of critical tumor suppressors in mice to evaluate the consequences on
cancer, aging and general organismal fitness. The tumor suppressors
p53 and p16/ARF are among the most important sensors of stress, their
activation is meant to eliminate damaged cells and thus prevent the
appearance of tumors. Aging has long been considered to be the result
of the accumulation of cellular damage. Based on this, we have
reasoned that improving the efficiency of these checkpoints should
decrease the burden of damaged cells and therefore should delay aging.
I will present data on the aging of mice with increased p53, or with
increase p16/Arf, or with combined increase of the above tumor
suppressors. Also, I will present data on the impact of p53 dosage on
telomere-driven aging.
Key words:
p53, p16INK4a, ARF, cancer, stress
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