| Wednesday 7th September |
| 11:00-13:15: Registration |
| 13:15 | Aubrey de Grey
University of Cambridge |
Welcome and introductory remarks |
| Session 1: Tissue regeneration and engineering
(Chair: Bob Lightowlers) |
| 13:20 | Tony Atala
Wake Forest University |
Tissue engineering, stem cells and cloning: current concepts and changing trends |
| 13:50 | Buddy Ratner
University of Washington |
To engineer a heart |
| 14:20 | Ellen Heber-Katz
Wistar Institute |
Can continuous regeneration lead to immortality? Studies in the MRL mouse |
| 14:50 | Gregory Fahy
21st Century Medicine |
Cryopreservation of complex living systems: the missing link in the regenerative medicine supply chain |
| 15:20 | Coffee |
| Session 2: Frontiers of somatic gene and enzyme therapy (Chair: Buddy Ratner) |
| 15:40 | Matthew Porteus
University of Texas |
Using zinc finger nucleases to manipulate the mammalian genome |
| 16:10 | Weihong Pan
Pennington Biomedical Research Center |
Delivery of enzymes and neurotrophic proteins to treat CNS disorders |
| 16:40 | James Larrick
Transomix, Inc. |
Revolutionizing transgenesis and gene disruptions using P-element transposition |
| 17:10 | Fulvio Mavilio
U. Modena and MolMed S.p.A. |
Genetic modification of hematopoietic stem cells: from bench to bedside....and back |
| 17:40 | Coffee |
| Session 3: Overcoming mitochondrial mutations (Chair: Fulvio Mavilio) |
| 18:00 | Bob Lightowlers
University of Newcastle |
Nucleic acid delivery to mitochondria - myth or reality? |
| 18:30 | Takao Yagi
Scripps Institute |
Can a single subunit NADH dehydrogenase rescue complex I defects? |
| 19:00 | Rafal Smigrodzki
Gencia Corporation |
Microheteroplasmy and protofection - the why and how of mtDNA replacement therapy |
| 19:30 | Henry Weiner
Purdue University |
Factors that might affect the allotopic replacement of a damaged mitochondrial DNA-encoded protein |
| 20:00 | Dinner |
| 21:00 | Welcome reception and Poster session 1 |
| Thursday 8th September |
| 7:30 | Breakfast |
| Session 4: Stem cell therapies in the clinic (Chair: Judd Aiken) |
| 8:30 | Amit Patel
University of Pittsburgh |
Does stem cell therapy for ischemic cardiomyopathy result in the improvement of congestive heart failure? |
| 9:00 | James Conner
University of California San Diego |
Ex vivo gene delivery of NGF in Alzheimer's Disease |
| 9:30 | Paul Sharpe
King's College London |
Tissue engineering teeth |
| 10:00 | Chang-Hun Song
Chosun University |
Clinical application of human umbilical cord blood mesenchymal stem cells |
| 10:30 | Coffee |
| Session 5: Overcoming sarcopenia, adiposity and their sequelae (Chair: Matthias Stelzner) |
| 10:50 | Judd Aiken
University of Wisconsin-Madison |
The role of mtDNA deletion mutations in sarcopenia |
| 11:20 | Irina Conboy
University of California Berkeley |
Understanding and reversing aging of muscle precursor cells |
| 11:50 | Roger Unger
University of Texas |
Leptin and longevity: blocking the consequences of lipid overload |
| 12:20 | Ronald Kahn
Joslin Institute |
Role of insulin action and gene expression in adipose tissue in aging |
| 12:50 | Lunch |
| Session 6: short talks: immunosenescence, growth factors, other (Chairs: Alexander Bürkle, Russ Hepple)
|
| 13:50 | Alexander Bürkle
University of Konstanz |
Poly(ADP-ribosyl)ation capacity of human T lymphocytes in vitro and in vivo as a function of age |
| 14:05 | Calogero Caruso
University of Palermo |
Biology of longevity: role of the immune system |
| 14:20 | Stanley Primmer
Los Angeles Gerontology Research Group |
The Supercentenarian Research Foundation |
| 14:35 | Andrew Dillin
Salk Institute |
SMK-1, an essential regulator of DAF-16/FOXO3a mediated longevity |
| 14:50 | Russell Hepple
University of Calgary |
Caloric restriction protects mitochondrial function with aging in skeletal and cardiac muscles |
| 15:05 | Eugenio Mocchegiani
Istituto Nazionale Riposo e Cura Anziani |
Zinc homeostasis in aging: two elusive faces of the same metal |
| 15:20 | D. James Morré
Purdue University |
Aging-related cell surface ECTO-NOX protein, arNOX, a preventive target to reduce atherogenic risk in the elderly |
| 15:35 | Chris Heward
Kronos Science Laboratory |
Negligible senescence - how will we know it when we see it? |
| 15:50 | Coffee |
| Session 7: SCNT and stem cells (1) (Chair: Paul Schiller) |
| 16:10 | Woo Suk Hwang
Seoul National University |
Patient-specific embryonic stem cells derived from human SCNT-blastocysts |
| 16:40 | José Cibelli
Michigan State University |
Parthenogenetic embryonic stem cells in primates |
| 17:10 | Gerald Schatten
University of Pittsburgh |
Aging research enabled by patient-specific embryonic stem cells derived from human SCNT-blastocysts |
| 17:40 | Coffee |
| Session 8: SCNT and stem cells (2) (Chair: Jerry Schatten) |
| 18:00 | Geoff Margison
Paterson Institute |
Protection and selection for gene therapy in the haemopoietic system |
| 18:30 | Teresa Holm (Jaenisch lab)
Massachusetts Institute of Technology |
Global loss of imprinting in embryonic stem cells leads to widespread tumorigenesis in adult mice |
| 19:00 | Paul Schiller
University of Miami |
Sustained stromal stem cell self-renewal and osteoblastic differentiation during aging |
| 19:30 | Matthias Stelzner
Greater Los Angeles Health Care System |
To make a new intestinal mucosa |
| 20:00 | Dinner |
| 21:00 | Poster session 2 |
| Friday 9th September |
| 7:30 | Breakfast |
| Session 9: Ellison Medical Foundation Session: Removal of intracellular aggregates (1) (Chair: Ana Maria Cuervo) |
| 8:30 | Bruce Rittmann
Arizona State University |
The microbiological foundation for bioremediating intracellular aggregates |
| 9:00 | Janet Sparrow
Columbia University |
The lipofuscin of the retinal pigment epithelium |
| 9:30 | Jay Jerome
Vanderbilt University |
Abnormal lysosomal processing of internalized cholesteryl esters in macrophages |
| 10:00 | Wendy Jessup
University of New South Wales |
Oxidized lipids in atherosclerotic macrophages: what role do they play in foam cell formation? |
| 10:30 | Coffee |
| Session 10: Ellison Medical Foundation Session: Removal of intracellular aggregates (2) (Chair: Jay Jerome) |
| 10:50 | David Rubinsztein
University of Cambridge |
Macroautophagy upregulation - a candidate therapeutic strategy to enhance clearance of toxic intracellular aggregate-prone proteins |
| 11:20 | Ralph Nixon
Nathan Kline Institute |
Autophagy in Alzheimer's Disease Pathogenesis |
| 11:50 | Ana Maria Cuervo
Albert Einstein College of Medicine |
Reactivating chaperone-mediated autophagy: the advantages of preserving a selective autophagy |
| 12:20 | Roscoe Brady
National Institutes of Health |
Current and future stategies for the treatment of metabolic storage disorders |
| 12:50 | Lunch |
| SENS Lecture (Chair: Aubrey de Grey) |
| 13:50 | Michael West
Advanced Cell Technology |
Strategies for the reversal of the aging of human somatic cells |
| Session 11: short talks: aggregate- and crosslinking-related aspects of aging (Chair: Aubrey de Grey) |
| 14:35 | Elizabeth Corder
Duke University |
Membership in high-risk genetic groups predicts Alzheimer's disease and age-at-onset |
| 14:50 | Stuart Wilson
PAD Pharma |
Tackling the diseases of old age; progress towards an Alzheimer's therapeutic |
| 15:05 | Ruth Itzhaki
University of Manchester |
Herpes simplex virus type 1 in brain and apolipoprotein E type 4 allele: a dangerous liaison for Alzheimer's disease |
| 15:20 | John Furber
Legendary Pharmaceuticals |
Glucosepane crosslink breakers: necessity and prospects |
| 15:35 | Shalesh Kaushal
University of Florida |
Manipulating the intracellular fate of an aggregate-prone protein |
| 15:50 | Coffee |
| Session 12: Immune modulation (rejuvenation and tolerisation) (1) (Chair: Graham Pawelec) |
| 16:10 | Susan Swain
Trudeau Institute |
The Impact of Aging on CD4 T Cell Function |
| 16:40 | Deborah Dunn-Walters
King's College London |
Antibody quality in old age |
| 17:10 | Matthias Reddehase
University of Mainz |
Immune sensing of latent cytomegalovirus reactivation and its possible impact on immune senescence |
| 17:40 | Coffee |
| Session 13: Immune modulation (rejuvenation and tolerisation) (2) (Chair: Deborah Dunn-Walters) |
| 18:00 | Michael Sela
Weizmann Institute |
Immunomodulatory vaccines against autoimmune diseases |
| 18:30 | Megan Sykes
Harvard University |
Immune tolerance induction: From bench to bedside |
| 19:00 | Marilyn Thoman
Sidney Kimmel Cancer Center
|
Thymic rejuvenation by engineered cells secreting IL-7 in situ |
| 19:30 | Graham Pawelec
University of Tübingen |
Immunorejuvenation in the elderly |
| 20:00 | Dinner |
| 21:00 | Poster session 3 |
| Saturday 10th September |
| 7:30 | Breakfast |
| Session 14: 21st-century anti-cancer therapies (1) (Chair: Dorothy Morré) |
| 8:30 | Bob Marciniak
University of Texas |
A novel form of ALT telomere maintenance in human cells |
| 9:00 | Edwin Goodwin
Los Alamos National Laboratory |
Telomere dynamics and cell proliferation |
| 9:30 | Maria Blasco
Spanish National Cancer Centre |
Telomeres and human disease: a matter of bad ends |
| 10:00 | Aubrey de Grey
University of Cambridge |
WILT: still crazy after both these years? |
| 10:30 | Coffee
|
| Session 15: 21st-century anti-cancer therapies (2) (Chair: Ed Goodwin) |
| 10:50 | Judith Campisi
Lawrence Berkeley National Laboratory |
Cellular senescence, cancer and aging |
| 11:20 | Manuel Serrano
Spanish National Cancer Center |
Mice with improved systems for cellular quality control: super-p53 and super-p16/ARF mice |
| 11:50 | Daniel Meruelo
New York University |
Gene therapy that safely targets and kills tumor cells throughout the body |
| 12:20 | Dorothy Morré
Purdue University |
Catechin-vanilloid synergies with potential clinical applications in cancer |
| 12:50 | Lunch |
| Session 16: short talks: cell number control (stem cells, SCNT, proliferation, senescence, apoptosis, cancer) (Chairs: Gabi Saretzki, Diana van Heemst) |
| 13:50 | Alexandra Stolzing
University of Sheffield |
Senescence in mesenchymal stem cells: the effects of reduced culture temperature and media glucose concentration |
| 14:05 | John Allen
Queen Mary, University of London |
Sex as a division of labour between mitochondria |
| 14:20 | Andrei Rybouchkin
Kinki University |
Enhanced reprogramming to facilitate production of somatic cell NT ES cell lines |
| 14:35 | Gabriele Saretzki
Newcastle University |
Telomerase decreases ROS levels but does not counteract telomere shortening under oxidative stress |
| 14:50 | Yousin Suh
University of Texas |
Apoptosis, genome maintenance, and aging |
| 15:05 | Diana van Heemst
Leiden University Medical Center |
Cellular ageing in fibroblast cultures from elderly aged 90 years old |
| 15:20 | Werner Zwerschke
Austrian Academy of Sciences |
Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin/proteasome-dependent proteolysis |
| 15:35 | Karl Riabowol
University of Calgary |
Chromatin remodeling may enforce cell senescence |
| 15:50 | Coffee |
| Session 17: Repair/removal of pathogenic extracellular material (1) (Chair: Matthew Collins) |
| 16:10 | Dean Jones
Emory University |
Extracellular redox state: refining the definition of oxidative stress in aging |
| 16:40 | Vincent Monnier
Case Western Reserve University |
Enzymic repair and prevention of chemical aging by the Maillard reaction in vivo |
| 17:10 | Howard Haimes
Alteon Pharmaceuticals |
Alagebrium: Intervention on the A.G.E. pathway modifies deficits caused by aging and diabetes |
| 17:40 | Coffee |
| Session 18: Repair/removal of pathogenic extracellular material (2) (Chair: Vincent Monnier) |
| 18:00 | Matthew Collins
University of York |
The decay of extra-cellular matrix proteins; an inevitable consequence of old age? |
| 18:30 | Vernon Ingram
Massachusetts Institute of Technology |
Alzheimer's, Huntington's and Prion Diseases - why are misfolded proteins so interesting, but so destructive? |
| 19:00 | Cynthia Lemere
Harvard University |
A-beta immunotherapy: lessons from mice, monkeys, and men |
| 19:30 | Mark Pepys
Royal Free & University College Medical School |
Ageing, amyloid and amyloidosis: from pathogenesis to therapy |
| 20:00 | Gala Dinner |
| Sunday 11th September |
| 7:30 | Breakfast |
| 9:30 | Punting on the Cam |
| 11:30 | C O N F E R E N C E A D J O U R N S |
| Thank you for your attendance and participation! |