Tag Archives: doctor

Scientists Correct Mutated Gene that Causes Sickle Cell Disease in Stem Cells

baby-sickle-vell

For the first time, scientists were able to correct the genetic mutation that causes sickle cell disease in stem cells.

In a collaborative effort, researchers at UC Berkeley, UC San Francisco Benioff Children’s Hospital Oakland Research Institute (CHORI), and the University of Utah School of Medicine fixed the mutation in modified stem cells from patients with the condition using a CRISPR/Cas9 gene editing approach.

The study, “Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells,” was published in the journal Science Translational Medicine.

The scientists hope to re-infuse patients with the modified stem cells and alleviate disease symptoms.

“We’re very excited about the promise of this technology,” Jacob Corn, senior author on the study and scientific director of the Innovative Genomics Initiative at UC Berkeley, said in a news release. “There is still a lot of work to be done before this approach might be used in the clinic, but we’re hopeful that it will pave the way for new kinds of treatment for patients with sickle cell disease.”

The researchers observed in mice tests that after transplants, the modified stem cells stuck around for about four months, an important target of the long-lasting potential of any therapy.

“This is an important advance because for the first time we show a level of correction in stem cells that should be sufficient for a clinical benefit in persons with sickle cell anemia,” said Mark Walters, a pediatric hematologist and oncologist and director of UCSF Benioff Oakland’s Blood and Marrow Transplantation Program and co-author of the study.

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Irish scientists discover way to ‘print’ new bones to help those with deformities and catastrophic injuries

 

Trinity College
Trinity College

BY PAT FLANAGAN

Irish scientists have developed a revolutionary new process which allows them to make human bones using 3D printing.

The new process could eliminate the need for bone grafts and could even make new joints to replace hips and knees and offers hope to those with large and complex bone defects or who have suffered catastrophic injuries.

 

In the future the process will allow bones to be repaired or even replaced cutting out the need for bone grafts.  Scientists at the Science Foundation Ireland-funded AMBER materials science centre at Dublin’s Trinity College have developed the new method of making bone material.  This is done using 3D bioprinting technology to construct cartilage templates in the shape of the missing bones.

When this is done the made up bone and stem cells is implanted under the skin, where it matures in time into fully functioning replacement bone with its own blood vessels.

The team, headed by Professor Daniel Kelly hope that in the future the development could lead to numerous applications in areas like head, jaw and spinal surgery.  READ MORE

Vascular Tissue Challenge Introduction Webinar

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Event Description

The Vascular Tissue Challenge is a $500,000 prize purse for the creation ofthick, human vascularized organ tissue in an in-vitro environment that maintains metabolic functionality similar to in vivo native cells throughout a 30-day trial period. The Methuselah Foundation’s New Organ Alliance and NASA’s Centennial Challenges Program have partnered to create this challenge with the goal of advancing research on human physiology, fundamental space biology, and medicine taking place both on the Earth and the ISS National Laboratory.

Additionally, the Center for Advancement of Science in Space (CASIS) will be providing an additional “Innovations in Space” Award covering $200,000 in hardware costs and the launch costs to send one team’s vascular tissue experiment to the International Space Station that could further their research in the field.

This introductory webinar is for anyone interested in potentially competing for the Vascular Tissue Challenge. In the webinar we will discuss the following items:

  1. Introduction to the Methuselah Foundation, New Organ Alliance, and NASA Centennial Challenges.
  2. Goals of the Vascular Tissue Challenge.
  3. Rules & evaluation criteria review.
  4. Innovations in Space Awardresearch opportunity using microgravity environment onboard the ISS.
  5. Processes and Procedures to compete.
  6. Question & Answer session.

Registration is free, but is required. The web address for the webinar will be emailed to webinar registrants prior to the event.

WHEN

Episode 007 – Control Alt Delete Cancer Research into longevity, human health, ageing, New Organ Research including bioprinting liver, kidney, and other medical pursuits

 

Control Alt Del

Hello and welcome to Episode 7!  On this episode, we’ll talk with Dr. Haroldo Silva and David Halvorsen of the SENS Research Foundation.  They’ve launched a new crowdfunding campaign designed to attack and stop cancer using a new approach.  You’ll hear what that approach is, why they think it has a good chance of success, and you can help in the fight.

If you’d like to comment on the show, have a question or want to reach us, write Rod.Wheaton@MFoundation.org

To learn how you can help the Methuselah Foundation continue its mission to extend heathy human life, CLICK HERE

NASA’s Vascular Tissue Challenge to help in study of deep space environmental effects

NASA’s Vascular Tissue Challenge to help in study of deep space environmental effects

Those working in the field of bioengineering should be ready for a challenge worth $500,000. NASA, along with the nonprofit Methuselah Foundation’s New Organ Alliance, has introduced the new prize competition, named as the Vascular Tissue Challenge. The first three teams that will succeed in creating thick, metabolically-functional human vascularized organ tissue in a controlled laboratory environment will be offered the prize money.

The participants in the competition have to produce vascularized tissue that is more than .39 inches in thickness and one that would offer over 85% of survival to required cells throughout a 30-day trial period. The teams in order to succeed should conduct three trials with at least a 75% of success rate. Moreover, teams must submit a proposal on ways to advance some aspect of their research further through a microgravity experiment, which would be conducted in the US National Laboratory on the International Space Station.

Tissue is a combination of related cells joined together to function as…to read more, CLICK HERE

Longevity, ageing, research, cancer, new organs, bioprinting, nasa, sens, age, human, health,kidney,liver,transplant,organ,doctor,grants

Episode 006 – Could Cryopreservation for Human Organs Save 700,000 – 900,000 Lives a Year?

 

Transplanting Organs

Join us on this episode of the Methuselah 300 Podcast as we interview Dr. Sebastian Eriksson Giwa;  co-founder and chairman of the Organ Preservation Alliance and co-founder and CEO of Sylvatica Biotech.  Dr. Giwa will discuss how Cryopreservation could transform and revolutionize transplantation Currently at least 1 in 5 people on the organ waiting list die due to the inability of keeping organs viable for transport, resulting in 700,000 deaths a year by some estimates.  Dr Giwa and his team want to change that…

The Defense Department, National Science Foundation and even the White House are beginning to recognize the need and potential of this scientific frontier , and scientists from around the world to an increasing decree are tackling the remaining challenges.  

Will you join us?  You can find out how to become a foundation supporter at  Mfoundation.org.

We thank you for your support now and in the future!

Sincerely,

Methuselah Foundation

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Episode 005 with Dr John Geibel; Yale University How Yale's Team of Researchers are Moving Toward 3-D Printable Organs

 

Faculty portraits
John Giebel, Director of Surgical Research, Yale University

On this week’s podcast, join us as we talk with Dr John Geibel, Director of Surgical Research and Professor of Department of Cellular and Molecular Physiology at Yale University.  Discover how his team is working hard to develop the first iterations of 3-D printable organs, a goal that will revolutionize the medical organ industry and save thousands upon thousands of lives.

To keep up with the latest developments, join our newsletter HERE

To find out how you can be a part of the Methuselah Foundation and support our work, go to Mfoundation.org or click HERE

Methuselah 300 Podcast Episode 004: Is a Synthetic Liver on the Horizon? With Dr Bryon Petersen A Synthetic Liver Could Bridge the Gap Between Now and the Development of an Real Tissue New Organ

Could this device bridge the gap to new organs?

Join us on this week’s podcast as we interview Dr. Bryon Petersen, who is researching and developing a new device that could bridge the gap for those awaiting a new liver so that those in need can have a quality of life impossible for them now.  You’ll here about where he is in the stage of development, and what timeline he is working toward.

To keep up with the latest developments, join our newsletter HERE

To find out how you can be a part of the Methuselah Foundation and support our work, go to Mfoundation.org or click HERE

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Longevity, ageing, research, cancer, new organs, bioprinting, nasa, sens, age, human, health,kidney,liver,transplant,organ,doctor,grants