Tag Archives: health

Scientists Correct Mutated Gene that Causes Sickle Cell Disease in Stem Cells

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For the first time, scientists were able to correct the genetic mutation that causes sickle cell disease in stem cells.

In a collaborative effort, researchers at UC Berkeley, UC San Francisco Benioff Children’s Hospital Oakland Research Institute (CHORI), and the University of Utah School of Medicine fixed the mutation in modified stem cells from patients with the condition using a CRISPR/Cas9 gene editing approach.

The study, “Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells,” was published in the journal Science Translational Medicine.

The scientists hope to re-infuse patients with the modified stem cells and alleviate disease symptoms.

“We’re very excited about the promise of this technology,” Jacob Corn, senior author on the study and scientific director of the Innovative Genomics Initiative at UC Berkeley, said in a news release. “There is still a lot of work to be done before this approach might be used in the clinic, but we’re hopeful that it will pave the way for new kinds of treatment for patients with sickle cell disease.”

The researchers observed in mice tests that after transplants, the modified stem cells stuck around for about four months, an important target of the long-lasting potential of any therapy.

“This is an important advance because for the first time we show a level of correction in stem cells that should be sufficient for a clinical benefit in persons with sickle cell anemia,” said Mark Walters, a pediatric hematologist and oncologist and director of UCSF Benioff Oakland’s Blood and Marrow Transplantation Program and co-author of the study.

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These companies search for a cure to aging– and their discoveries are amazing

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The ideas surrounding life enhancement are not new—in fact, records show an interest in the mysteries surrounding human life for centuries.

Mary Shelley’s Frankenstein explores the idea of creating a life, while Doctor Who achieves life extension through regeneration. Wolverine’s mutations let him heal away his problems, and Captain America froze himself into the 21st century. Just look at almost any Star Trek episode and you’ll see how fascinated people are with the idea of extending life.

These ideas are starting to extend beyond science fiction. What was once seen as fiction is, in fact, highly relevant in today’s scientific community. Life extension research lives in academia at the moment, but it’s also graining traction in nonprofit foundations and national organizations.

This scientific field aims not only to discover the solutions to life’s unanswered aging questions, but also allow humanity to “live long and prosper.”

Why bother with this research?

The “holy grail” of the life extension industry is the cure to aging (obviously) and its discovery would change the course of human history forever.

However, when looking at life extension from the viewpoint of the Average Joe, there are many very real, personal, and emotional reasons which can be tied to the desire for those extra years.

“Seeing friends and family age can be difficult to go through,” said Dr. Chris Barton, assistant professor of biology at Belmont University in Nashville, TN. “As a result, I think that we are becoming more conscious of the aging process and more intentional about trying to find ways to delay it.”

When did life extension research really begin?

 

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Hopefully Calico doesn’t go the way of Google Glass. (Credit: Calico)

Interest in life extension has existed for decades– one of the largest booms in life extension research began in the 1990s. In 1992, The American Academy of Anti-Aging Medicine was established to explore the mysteries behind our bodies’ aging process.

From then the new millennium began, and with it came companies such as the Methuselah Foundation, co-founded by Dave Gobel and Dr. Aubrey de Grey in 2003, and through its leadership came the “Strategies for

Engineered Negligible Senescence,” or SENS Research Foundation, founded in 2009. In 2013, Google announced its new company Calico, who under the leadership of Arthur D. Levinson would focus on human health in relation to aging and its associated diseases.

“Nothing breeds success better than success,” Dr. Barton explained when reviewing the recent boom in anti-aging research out of these foundations. “While many of these advancements are in basic science research, it is really this foundational understanding of aging that has allowed us to detect and treat numerous aging-related diseases.

“If you look at the life expectancy data from 1960 to today, people are clearly living longer”—life expectancy in the United States alone jumped from age 70 in 1960 to age 79 in 2014, according to The World Bank. “We are currently more effective in treating conditions such as cardiovascular disease, cancer, and other aging-related diseases than we were 30 years ago. I think the recent success we’ve had in these areas is developing an excitement for aging research that can perhaps generate discoveries and technologies that may even further extend our life expectancy,” he continued.

The different areas of life extension research

These companies challenge current researchers and scientists to study the mysteries surrounding aging. The Methuselah Foundation focuses on Organovo and the ability to 3D print functional human tissues with hopes of creating functioning organs, while the SENS Research Foundation focuses on rejuvenation biotechnologies with new therapies which target and repair molecular damage responsible for the body’s aging.

With a Ph. D. in Biochemistry from Vanderbilt University and specializations in physiology, cell biology, and molecular genetics, Dr. Barton was able to provide insight into one of the many areas of research currently being studied among those in the field of life extension and anti-aging.

“Perhaps one of the most popular views behind the aging process is the ‘stem cell theory of aging,’ which states that as we age, our stem cells aren’t able to continue dividing to replenish the cells that are being lost in our tissues and organs,” Dr. Barton explained, believing this to be an area of research holding great promise.

“In addition, every time a cell divides there is the potential for it to accumulate some type of damage to its DNA. Given that stem cells must divide over an entire lifetime, they tend to accumulate quite a bit of damage. It is really the inability of our stem cells to continue growing indefinitely that many believe is the root of the aging process. Without a healthy pool of stem cells, tissues and organs are no longer able to maintain themselves in a way that supports life.”

 

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Learning how to reverse cell damage could be the key to reversing aging. (Credit: Thinkstock)

The hope for researchers is to promote the field and provide the world with a hope for advancement and, one day, a solution.

“Scientific progress, particularly in academia, is most often hindered by the decreases in government funding,” Dr. Barton said. “When large organizations such as these are willing to contribute funds or resources in order to advance research on a specific topic, I think they immediately become relevant to the larger research community.”

And, in the case of anti-aging and life extension research communities, the relevancy of their research extends much further than that in everyday culture, aging treatments, diseases associated with aging, life expectancy, and the overall quality of life every single person will one day encounter with age.

So why haven’t we found the solution to aging yet?

Read more at http://www.redorbit.com/news/technology

Methuselah Foundation Fellowship Award Winner Tackles Research in Macular Degeneration 

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Typically, a fellowship and participation in a research study to cure a major disease would occur years after completing undergrad, possibly even after earning a PhD. But Jennifer DeRosa is not a typical student.

As early as high school, DeRosa was already in the lab, conducting research in plant biotechnology at the College of Environmental Science and Forestry (SUNY-ESF) before graduating valedictorian from Skaneateles High School. As a freshman student at Onondaga Community College, she continued to develop skills in molecular biology, analytical chemistry, and cell biology. She logged over 1,600 hours in academic and industry laboratories while maintaining a perfect 4.0 GPA, completing her associate’s degree in Math and Science in only one year.

Although she had planned to continue to a bachelor’s program, DeRosa elected to defer enrollment after being offered a Methuselah Foundation research fellowship. “The fellowship provides distinguished students a year-long stipend to work in any laboratory of their choosing that conducts work on age-associated diseases,” said Methuselah Foundation CEO David Gobel. “We are very pleased that she chose to complete her fellowship at Ichor Therapeutics, where she has been working as a paid intern. Methuselah Foundation has a high degree of confidence in the quality and scope of work being conducted there.”

Her enthusiasm for her work has caught the attention of everyone who works with her. “Jennifer [DeRosa] has distinguished herself at every level since beginning as an intern in January,” stated Ichor’s Quality Assurance Director Scott Campbell. “We are delighted about her decision to stay on and help us drive our age-related macular degeneration program into the next stage of development, including adopting of stringent GMP and GLP regulatory requirements.”

DeRosa is excited about the research that Ichor Therapeutics is currently engaged in, as well as the opportunities to learn in areas beyond the science itself. She said, “I chose to intern at Ichor because as a startup, I knew it would allow me to explore entrepreneurship and take on a greater role than I otherwise could at a large company. Between being able to participate in board meetings, discuss legal and translational strategy with Ichor’s counsel and advisory teams, and meeting the company’s investors to better understand their expectations – Let’s just say it was a simple decision for me to remain here.”

DeRosa’s previous research at Ichor substantially and directly contributed to the company successfully raising $600,000 for its macular degeneration program earlier this summer. DeRosa was a listed author on both the research proposal and business plan, and is also listed on two pending grant applications.

Kelsey Moody, CEO at Ichor Therapeutics, noted, “The most difficult part of having her here is finding sufficient challenges. She has earned complete autonomy since her arrival. Beyond her expansive laboratory skills, she has designed her own studies, written proposals for grants, and led a small team to develop product leads for the macular-degeneration program.”

When her fellowship draws to a close, DeRosa intends to pursue a bachelor’s degree or matriculate directly into a graduate program. However, she plans to remain opportunistic. “The pace, progress, and potential impact of Ichor’s macular degeneration program is addicting. The company’s main focus now is to prepare for series A, after which, who knows what opportunities may present themselves.” 

Vascular Tissue Challenge Introduction Webinar

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Event Description

The Vascular Tissue Challenge is a $500,000 prize purse for the creation ofthick, human vascularized organ tissue in an in-vitro environment that maintains metabolic functionality similar to in vivo native cells throughout a 30-day trial period. The Methuselah Foundation’s New Organ Alliance and NASA’s Centennial Challenges Program have partnered to create this challenge with the goal of advancing research on human physiology, fundamental space biology, and medicine taking place both on the Earth and the ISS National Laboratory.

Additionally, the Center for Advancement of Science in Space (CASIS) will be providing an additional “Innovations in Space” Award covering $200,000 in hardware costs and the launch costs to send one team’s vascular tissue experiment to the International Space Station that could further their research in the field.

This introductory webinar is for anyone interested in potentially competing for the Vascular Tissue Challenge. In the webinar we will discuss the following items:

  1. Introduction to the Methuselah Foundation, New Organ Alliance, and NASA Centennial Challenges.
  2. Goals of the Vascular Tissue Challenge.
  3. Rules & evaluation criteria review.
  4. Innovations in Space Awardresearch opportunity using microgravity environment onboard the ISS.
  5. Processes and Procedures to compete.
  6. Question & Answer session.

Registration is free, but is required. The web address for the webinar will be emailed to webinar registrants prior to the event.

WHEN

Episode 007 – Control Alt Delete Cancer Research into longevity, human health, ageing, New Organ Research including bioprinting liver, kidney, and other medical pursuits

 

Control Alt Del

Hello and welcome to Episode 7!  On this episode, we’ll talk with Dr. Haroldo Silva and David Halvorsen of the SENS Research Foundation.  They’ve launched a new crowdfunding campaign designed to attack and stop cancer using a new approach.  You’ll hear what that approach is, why they think it has a good chance of success, and you can help in the fight.

If you’d like to comment on the show, have a question or want to reach us, write Rod.Wheaton@MFoundation.org

To learn how you can help the Methuselah Foundation continue its mission to extend heathy human life, CLICK HERE

NASA’s Vascular Tissue Challenge to help in study of deep space environmental effects

NASA’s Vascular Tissue Challenge to help in study of deep space environmental effects

Those working in the field of bioengineering should be ready for a challenge worth $500,000. NASA, along with the nonprofit Methuselah Foundation’s New Organ Alliance, has introduced the new prize competition, named as the Vascular Tissue Challenge. The first three teams that will succeed in creating thick, metabolically-functional human vascularized organ tissue in a controlled laboratory environment will be offered the prize money.

The participants in the competition have to produce vascularized tissue that is more than .39 inches in thickness and one that would offer over 85% of survival to required cells throughout a 30-day trial period. The teams in order to succeed should conduct three trials with at least a 75% of success rate. Moreover, teams must submit a proposal on ways to advance some aspect of their research further through a microgravity experiment, which would be conducted in the US National Laboratory on the International Space Station.

Tissue is a combination of related cells joined together to function as…to read more, CLICK HERE

Longevity, ageing, research, cancer, new organs, bioprinting, nasa, sens, age, human, health,kidney,liver,transplant,organ,doctor,grants

BREAKING: Methuselah Partnering with NASA

June 13, 2016

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NASA Challenge Aims to Grow Human Tissue to Aid in Deep Space Exploration

NASA, in partnership with the nonprofit Methuselah Foundation’s New Organ Alliance, is seeking ways to advance the field of bioengineering through a new prize competition.

The Vascular Tissue Challenge offers a $500,000 prize to be divided among the first three teams that successfully create thick, metabolically-functional human vascularized organ tissue in a controlled laboratory environment.

“The humans who will be our deep space pioneers are our most important resource on the Journey to Mars and beyond,” said Steve Jurczyk, associate administrator for NASA’s Space Technology Mission Directorate in Washington. “The outcome of this challenge has the potential to revolutionize healthcare on Earth, and could become part of an important set of tools used to minimize the negative effects of deep space on our future explorers.”

Related cells that are joined together are collectively referred to as tissue, and these cells work together as organs to accomplish specific functions in the human body. Blood vessels around the cells vascularize, providing nutrients to the tissue to keep it healthy. The vascularized, thick-tissue models resulting from this challenge will function as organ analogs, or models, that can be used to study deep space environmental effects, such as radiation, and to develop strategies to minimize the damage to healthy cells. 

Studying these effects will help create ways to mitigate negative effects of space travel on humans during long duration, deep space missions. On Earth, the vascularized tissue could be used in pharmaceutical testing or disease modeling. The challenge also could accelerate new research and development in the field of organ transplants.

When the Wright Brothers discovered how to control aircraft during flight for aviation in the early 1900s, there was an explosion of progress after this key barrier was removed”, said Dave Gobel, chief executive officer of the Methuselah Foundation. “In the same way, once the ‘vascularization limit’ is solved, via the NASA Vascular Tissue Challenge, there inevitably will be an historic advance in progress and commercialization of tissue engineering applications to everyone’s benefit.”

Competitors must produce vascularized tissue that is more than .39 inches (1 centimeter) in thickness and maintains more than 85 percent survival of the required cells throughout a 30-day trial period. Teams must demonstrate three successful trials with at least a 75 percent success rate to win an award. In addition to the laboratory trials, teams also must submit a proposal that details how they would further advance some aspect of their research through a microgravity experiment that could be conducted in the U.S. National Laboratory on the International Space Station.

The new challenge was announced as part of White House Organ Summit, which highlighted efforts to improve outcomes for individuals waiting for organ transplants and support for living donors. In a related initiative, the Center for the Advancement of Science in Space (CASIS), which manages the International Space Station U.S. National Laboratory, announced a follow-on prize competition in partnership with the New Organ Alliance and the Methuselah Foundation that will provide researchers the opportunity to conduct research in microgravity conditions. CASIS will provide one team up to $200,000 in flight integration support costs, along with transportation to the ISS National Laboratory, support on station and return of experimental samples to Earth. CASIS also announced the winners of the $1 million 3-D Microphysiological Systems for Organs-On-Chips Grand Challenge.

The Vascular Tissue Challenge prize purse is provided by NASA’s Centennial Challenges Program, part of NASA’s Space Technology Mission Directorate. Centennial Challenges, managed by the agency’s Marshall Space Flight Center in Huntsville, Alabama, is NASA’s citizen inventor prize program that invites the nation to help advance the technologies that will enable us to go to Mars and beyond, as well as improve life on Earth. The New Organ Alliance, which is administering the competition on behalf of NASA, is a nonprofit organization focused on regenerative medicine research and development to benefit human disease research and tissue engineering.

For information about the Methuselah Foundation’s New Organ Alliance, official challenge documents, rules and schedule of events, visit:

https://neworgan.org/vtc-prize.php

For more information about the Vascular Tissue Challenge, visit:

http://www.nasa.gov/vtchallenge

Episode 006 – Could Cryopreservation for Human Organs Save 700,000 – 900,000 Lives a Year?

 

Transplanting Organs

Join us on this episode of the Methuselah 300 Podcast as we interview Dr. Sebastian Eriksson Giwa;  co-founder and chairman of the Organ Preservation Alliance and co-founder and CEO of Sylvatica Biotech.  Dr. Giwa will discuss how Cryopreservation could transform and revolutionize transplantation Currently at least 1 in 5 people on the organ waiting list die due to the inability of keeping organs viable for transport, resulting in 700,000 deaths a year by some estimates.  Dr Giwa and his team want to change that…

The Defense Department, National Science Foundation and even the White House are beginning to recognize the need and potential of this scientific frontier , and scientists from around the world to an increasing decree are tackling the remaining challenges.  

Will you join us?  You can find out how to become a foundation supporter at  Mfoundation.org.

We thank you for your support now and in the future!

Sincerely,

Methuselah Foundation

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Episode 005 with Dr John Geibel; Yale University How Yale's Team of Researchers are Moving Toward 3-D Printable Organs

 

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John Giebel, Director of Surgical Research, Yale University

On this week’s podcast, join us as we talk with Dr John Geibel, Director of Surgical Research and Professor of Department of Cellular and Molecular Physiology at Yale University.  Discover how his team is working hard to develop the first iterations of 3-D printable organs, a goal that will revolutionize the medical organ industry and save thousands upon thousands of lives.

To keep up with the latest developments, join our newsletter HERE

To find out how you can be a part of the Methuselah Foundation and support our work, go to Mfoundation.org or click HERE

Methuselah 300 Podcast Episode 004: Is a Synthetic Liver on the Horizon? With Dr Bryon Petersen A Synthetic Liver Could Bridge the Gap Between Now and the Development of an Real Tissue New Organ

Could this device bridge the gap to new organs?

Join us on this week’s podcast as we interview Dr. Bryon Petersen, who is researching and developing a new device that could bridge the gap for those awaiting a new liver so that those in need can have a quality of life impossible for them now.  You’ll here about where he is in the stage of development, and what timeline he is working toward.

To keep up with the latest developments, join our newsletter HERE

To find out how you can be a part of the Methuselah Foundation and support our work, go to Mfoundation.org or click HERE

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Longevity, ageing, research, cancer, new organs, bioprinting, nasa, sens, age, human, health,kidney,liver,transplant,organ,doctor,grants