What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

Here is a fun question... Can you name one hole in your body that, if sewn shut, would help you function better?

Assuming you have an anatomically normal body, the answer is none. While saying that "bad plumbing" causes Alzheimer's Disease is an oversimplification, it is a great way to quickly explain why we angel invested in Leucadia Therapeutics in 2015. The Principal Scientist, Founder, and CEO of Leucadia Therapeutics, Doug Ethell, Ph.D., had an Occam Razor's approach to AD, which was refreshing to us and an inspiration. As it turns out, the Cribriform Plate that drains cerebrospinal fluid can get ossified or clogged as you age. In AD patients, it is always significantly clogged, thus the "bad plumbing" analogy. 


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Decades and Billions of Dollars Have Been Lost in the War Against Alzheimer's Disease

Decades and Billions of Dollars Have Been Lost in the War Against Alzheimer's Disease

At Methuselah Foundation we understand that the war against AD is one that humanity cannot afford to loose. We applaud revisiting the roadmap that will lead us to a cure. Writer John Carroll analyses this imperative in the Endpoints News article titled "After yet another PhIII Alzheimer’s failure, experts try to map a path out of the wrecking field."

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Reconsidering Alzheimer's Disease

Reconsidering Alzheimer's Disease

In light of the underwhelming efficacy of human anti-Abeta clinical trials in the last several years, we are pleased to read the scientific community starting to reconsider the theory that amyloid beta (Abeta) is the primary causative factor in Alzheimer's disease. This paper is among several we've seen over the past year which criticizes the amyloid cascade hypothesis, and does a good job of balancing the supportive and contradictory evidence for the hypothesis.

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A Day in the Life of a 90-Year-Old

A Day in the Life of a 90-Year-Old

The elderly have wisdom of great value to all, but few listen. Their story is worth being heard. If things don’t change, we will all share their experience. This first-person narrative is the result of years of interviews and the extensive experience of a Registered Nurse specializing in Geriatrics. We invite you to live a day in the live of a 90 year old.

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Mark Your Calendars: 2018 Senescence Research Meetings

Mark Your Calendars: 2018 Senescence Research Meetings

One of the best way to meet others in our community and stay current  is to attend several conventions and events hosted by institutions focused on Longevity. The following is a list of events in chronological order that will add to your knowledge base. Special thanks to John D. Furber for compiling this comprehensive list!

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Has Human Longevity Really Plateaued?

Has Human Longevity Really Plateaued?

Many in our community were distraught when a paper published in Nature not only said that the maximum human lifespan had plateaued but also set that maximum number to 115 years. Thankfully, many discerning scientists decided to spend their resources understanding the data, the claims, and drawing their own conclusions. In this article by Gizmodo writer Ryan F. Mandelbaum brings to the surfaces some issues found in the world of publishing research data.

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Does Older Age Result in Loss of Our Civil Rights?

Does Older Age Result in Loss of Our Civil Rights?

Independence: That is just one of the many reason for wanting to live longer, healthier lives. In practice, elderly citizens from the United States and other nations can become vulnerable to extortion, manipulations and victims of unscrupulous guardians. The New Yorker's October 9, 2017 Issue contained an eye-opening article written by Rachel Aviv and titled: "How the Elderly Lose Their Rights."

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The Fable of the Dragon-Tyrant

The Fable of the Dragon-Tyrant

It has been thirteen years since Nick Bostrom published The Fable of the Dragon-Tyrant, a clear call to action regarding our relationship with aging and medical technology. Today we stand in the midst of revolutionary progress in biotechnology, and all of the old limits and incurable conditions might be addressed given sufficient funding and will. Has the public’s view of aging changed enough in the past thirteen years?

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Can We Cure Aging? - Analog Article

Can We Cure Aging? - Analog Article

How can science fiction affect our view of what is possible? In this article, quantum physics Professor John G. Cramer explains how he came to care for the longevity field and interviews Gary Hudson of Oisín Biotechnologies, a company that could make his Sci-Fi dreams a reality.

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Redesigned Site: New Blog Style

Redesigned Site: New Blog Style

What's new at Methuselah Foundation? What recent scientific data has you excited about the future of this field? What should I do in order to be a healthier longer live? These are questions we received on an on-going basis. That is why we've decided to change our blog in a way that adds value to our community. We will mainly act as an aggregator of media, with some original pieces sprinkled in between. We hope that this new format will have you coming back for more content!

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Vascular Tissue Challenge Update

Vascular Tissue Challenge Update

Last June, the Methuselah Foundation and NASA officially launched the Vascular Tissue Challenge (VTC) at the White House Organ Summit, hosted by the Office of Science and Technology Policy. The VTC includes a $500,000 prize purse from NASA for the first teams that can successfully create thick (>1cm), vascularized tissues that remain functional and alive for more than 30 days. Along with this is the Center for the Advancement of Science in Space’s (CASIS) “Innovations in Space Award,” providing an additional $200,000 to support a research opportunity onboard the International Space Station’s National Laboratory!

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Organovo Collaborates With Professor Melissa Little for Kidney Tissue Research

Organovo Collaborates With Professor Melissa Little for Kidney Tissue Research

SAN DIEGO and MELBOURNE, Australia and SPRINGFIELD, Va., Jan. 24, 2017 (GLOBE NEWSWIRE) -- Organovo Holdings, Inc. (NASDAQ:ONVO) (“Organovo”), a three-dimensional biology company focused on delivering scientific and medical breakthroughs using its 3D bioprinting technology, today announced a collaboration with Professor Melissa Little and the Murdoch Childrens Research Institute, The Royal Children’s Hospital, Melbourne, Australia to develop an architecturally correct kidney for potential therapeutic applications.  The collaboration has been made possible by a generous gift from the Methuselah Foundation (“Methuselah”) as part of its ongoing University 3D Bioprinter Program.

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Scientists Correct Mutated Gene that Causes Sickle Cell Disease in Stem Cells

Scientists Correct Mutated Gene that Causes Sickle Cell Disease in Stem Cells

For the first time, scientists were able to correct the genetic mutation that causes sickle cell disease in stem cells.

In a collaborative effort, researchers at UC Berkeley, UC San Francisco Benioff Children’s Hospital Oakland Research Institute (CHORI), and the University of Utah School of Medicine fixed the mutation in modified stem cells from patients with the condition using a CRISPR/Cas9 gene editing approach.

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NASA is offering a $500,000 prize to the first who can grow human organ tissue

NASA is offering a $500,000 prize to the first who can grow human organ tissue

NASA is challenging teams to create thick, metabolically-functional human vascularized organ tissue in a controlled lab setting. It's called the Vascular Tissue Challenge, and the first three teams to succeed will split a total prize of $500,000. It's a challenge, but a necessary one for getting NASA one step closer to sending humans to Mars.

Watch the video HERE

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These companies search for a cure to aging– and their discoveries are amazing

These companies search for a cure to aging– and their discoveries are amazing

The ideas surrounding life enhancement are not new—in fact, records show an interest in the mysteries surrounding human life for centuries.

Mary Shelley’s Frankenstein explores the idea of creating a life, while Doctor Who achieves life extension through regeneration. Wolverine's mutations let him heal away his problems, and Captain America froze himself into the 21st century. Just look at almost any Star Trek episode and you’ll see how fascinated people are with the idea of extending life.

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Irish scientists discover way to 'print' new bones to help those with deformities and catastrophic injuries

Irish scientists discover way to 'print' new bones to help those with deformities and catastrophic injuries

Irish scientists have developed a revolutionary new process which allows them to make human bones using 3D printing.

The new process could eliminate the need for bone grafts and could even make new joints to replace hips and knees and offers hope to those with large and complex bone defects or who have suffered catastrophic injuries.

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