The Methuselah Foundation Successfully Closes its Boutique Venture Fund

The Methuselah Foundation Successfully Closes its Boutique Venture Fund

The Methuselah Fund or M Fund is mission-oriented and was conceived after successful angel investments by the Methuselah Foundation. The M Fund's investment thesis is based on six strategies aimed at increasing healthy longevity and its current portfolio includes four exciting companies.

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Society for Gero-Engineering and Technology (SGET)

Society for Gero-Engineering and Technology (SGET)

For a while, we have seen that anti-aging is rapidly becoming an engineering challenge rather than a mere fantasy. To this point, our Foundation is also working on helping create a professional society focused on Geroengineering. Enter, the Society of Gero-Engineering and Technology, or SGET.

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N of One: An Experiment In Not Flying Breathlessly

N of One: An Experiment In Not Flying Breathlessly

On a recent trip to California, my goal was to document an aircraft’s actual interior cabin altitude, versus the altitude of that aircraft’s distance above the ground. Finding this altitude would tell me how much oxygen would be in the cabin, where lower altitudes would mean more available oxygen.

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What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

Here is a fun question... Can you name one hole in your body that, if sewn shut, would help you function better?

Assuming you have an anatomically normal body, the answer is none. While saying that "bad plumbing" causes Alzheimer's Disease is an oversimplification, it is a great way to quickly explain why we angel invested in Leucadia Therapeutics in 2015. The Principal Scientist, Founder, and CEO of Leucadia Therapeutics, Doug Ethell, Ph.D., had an Occam Razor's approach to AD, which was refreshing to us and an inspiration. As it turns out, the Cribriform Plate that drains cerebrospinal fluid can get ossified or clogged as you age. In AD patients, it is always significantly clogged, thus the "bad plumbing" analogy. 


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Reconsidering Alzheimer's Disease

Reconsidering Alzheimer's Disease

In light of the underwhelming efficacy of human anti-Abeta clinical trials in the last several years, we are pleased to read the scientific community starting to reconsider the theory that amyloid beta (Abeta) is the primary causative factor in Alzheimer's disease. This paper is among several we've seen over the past year which criticizes the amyloid cascade hypothesis, and does a good job of balancing the supportive and contradictory evidence for the hypothesis.

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A Day in the Life of a 90-Year-Old

A Day in the Life of a 90-Year-Old

The elderly have wisdom of great value to all, but few listen. Their story is worth being heard. If things don’t change, we will all share their experience. This first-person narrative is the result of years of interviews and the extensive experience of a Registered Nurse specializing in Geriatrics. We invite you to live a day in the live of a 90 year old.

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Redesigned Site: New Blog Style

Redesigned Site: New Blog Style

What's new at Methuselah Foundation? What recent scientific data has you excited about the future of this field? What should I do in order to be a healthier longer live? These are questions we received on an on-going basis. That is why we've decided to change our blog in a way that adds value to our community. We will mainly act as an aggregator of media, with some original pieces sprinkled in between. We hope that this new format will have you coming back for more content!

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