Another Threat to Our Longevity: Chronic Dosing and Overprescribing

Another Threat to Our Longevity: Chronic Dosing and Overprescribing

What happens when the industry created to keep you alive pushes products that ultimately aid in your death? We are often concerned about incentives in the healthcare industry to prescribe medicine when it is not necessary and even when a simple lifestyle change would achieve the same beneficial effects.

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The Investment Scene for Longevity is Heating Up!

The Investment Scene for Longevity is Heating Up!

Over 10 years ago, we realized that investing in longevity companies has a two-fold benefit. Such investments accelerate products into the market that we all benefit from and also pours more capital into private research, resulting in breakthroughs in the longevity space. 

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Want To Reduce Your Senescent Cells? An Argument For Diet-Induced Weight Loss

Want To Reduce Your Senescent Cells? An Argument For Diet-Induced Weight Loss

Cellular senescence is an increasingly popular topic. Dysfunctional cells have been implicated in numerous age-related dysfunctions. While the efforts to remove these senile cells have been growing, this study shows that at least one form of cellular senescence can be addressed without drugs or other high-tech interventions.

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Understanding Cell Reprogramming: The Promising Cautious Approach

Understanding Cell Reprogramming: The Promising Cautious Approach

The four "Yamanaka factors" have been known to induce pluripotency for some time. Forced expression of these four genes has been reported to turn an adult cell into what appears to be a pluripotent stem cell, with all that entails. However, this report illustrates that stem cell differentiation is a continuum.

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What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

Here is a fun question... Can you name one hole in your body that, if sewn shut, would help you function better?

Assuming you have an anatomically normal body, the answer is none. While saying that "bad plumbing" causes Alzheimer's Disease is an oversimplification, it is a great way to quickly explain why we angel invested in Leucadia Therapeutics in 2015. The Principal Scientist, Founder, and CEO of Leucadia Therapeutics, Doug Ethell, Ph.D., had an Occam Razor's approach to AD, which was refreshing to us and an inspiration. As it turns out, the Cribriform Plate that drains cerebrospinal fluid can get ossified or clogged as you age. In AD patients, it is always significantly clogged, thus the "bad plumbing" analogy. 


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Decades and Billions of Dollars Have Been Lost in the War Against Alzheimer's Disease

Decades and Billions of Dollars Have Been Lost in the War Against Alzheimer's Disease

At Methuselah Foundation we understand that the war against AD is one that humanity cannot afford to loose. We applaud revisiting the roadmap that will lead us to a cure. Writer John Carroll analyses this imperative in the Endpoints News article titled "After yet another PhIII Alzheimer’s failure, experts try to map a path out of the wrecking field."

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Reconsidering Alzheimer's Disease

Reconsidering Alzheimer's Disease

In light of the underwhelming efficacy of human anti-Abeta clinical trials in the last several years, we are pleased to read the scientific community starting to reconsider the theory that amyloid beta (Abeta) is the primary causative factor in Alzheimer's disease. This paper is among several we've seen over the past year which criticizes the amyloid cascade hypothesis, and does a good job of balancing the supportive and contradictory evidence for the hypothesis.

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Mark Your Calendars: 2018 Senescence Research Meetings

Mark Your Calendars: 2018 Senescence Research Meetings

One of the best way to meet others in our community and stay current  is to attend several conventions and events hosted by institutions focused on Longevity. The following is a list of events in chronological order that will add to your knowledge base. Special thanks to John D. Furber for compiling this comprehensive list!

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Has Human Longevity Really Plateaued?

Has Human Longevity Really Plateaued?

Many in our community were distraught when a paper published in Nature not only said that the maximum human lifespan had plateaued but also set that maximum number to 115 years. Thankfully, many discerning scientists decided to spend their resources understanding the data, the claims, and drawing their own conclusions. In this article by Gizmodo writer Ryan F. Mandelbaum brings to the surfaces some issues found in the world of publishing research data.

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Does Older Age Result in Loss of Our Civil Rights?

Does Older Age Result in Loss of Our Civil Rights?

Independence: That is just one of the many reason for wanting to live longer, healthier lives. In practice, elderly citizens from the United States and other nations can become vulnerable to extortion, manipulations and victims of unscrupulous guardians. The New Yorker's October 9, 2017 Issue contained an eye-opening article written by Rachel Aviv and titled: "How the Elderly Lose Their Rights."

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The Fable of the Dragon-Tyrant

The Fable of the Dragon-Tyrant

It has been thirteen years since Nick Bostrom published The Fable of the Dragon-Tyrant, a clear call to action regarding our relationship with aging and medical technology. Today we stand in the midst of revolutionary progress in biotechnology, and all of the old limits and incurable conditions might be addressed given sufficient funding and will. Has the public’s view of aging changed enough in the past thirteen years?

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Can We Cure Aging? - Analog Article

Can We Cure Aging? - Analog Article

How can science fiction affect our view of what is possible? In this article, quantum physics Professor John G. Cramer explains how he came to care for the longevity field and interviews Gary Hudson of Oisín Biotechnologies, a company that could make his Sci-Fi dreams a reality.

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Redesigned Site: New Blog Style

Redesigned Site: New Blog Style

What's new at Methuselah Foundation? What recent scientific data has you excited about the future of this field? What should I do in order to be a healthier longer live? These are questions we received on an on-going basis. That is why we've decided to change our blog in a way that adds value to our community. We will mainly act as an aggregator of media, with some original pieces sprinkled in between. We hope that this new format will have you coming back for more content!

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Vascular Tissue Challenge Update

Vascular Tissue Challenge Update

Last June, the Methuselah Foundation and NASA officially launched the Vascular Tissue Challenge (VTC) at the White House Organ Summit, hosted by the Office of Science and Technology Policy. The VTC includes a $500,000 prize purse from NASA for the first teams that can successfully create thick (>1cm), vascularized tissues that remain functional and alive for more than 30 days. Along with this is the Center for the Advancement of Science in Space’s (CASIS) “Innovations in Space Award,” providing an additional $200,000 to support a research opportunity onboard the International Space Station’s National Laboratory!

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