Another Threat to Our Longevity: Chronic Dosing and Overprescribing

Another Threat to Our Longevity: Chronic Dosing and Overprescribing

What happens when the industry created to keep you alive pushes products that ultimately aid in your death? We are often concerned about incentives in the healthcare industry to prescribe medicine when it is not necessary and even when a simple lifestyle change would achieve the same beneficial effects.

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The Investment Scene for Longevity is Heating Up!

The Investment Scene for Longevity is Heating Up!

Over 10 years ago, we realized that investing in longevity companies has a two-fold benefit. Such investments accelerate products into the market that we all benefit from and also pours more capital into private research, resulting in breakthroughs in the longevity space. 

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Want To Reduce Your Senescent Cells? An Argument For Diet-Induced Weight Loss

Want To Reduce Your Senescent Cells? An Argument For Diet-Induced Weight Loss

Cellular senescence is an increasingly popular topic. Dysfunctional cells have been implicated in numerous age-related dysfunctions. While the efforts to remove these senile cells have been growing, this study shows that at least one form of cellular senescence can be addressed without drugs or other high-tech interventions.

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Understanding Cell Reprogramming: The Promising Cautious Approach

Understanding Cell Reprogramming: The Promising Cautious Approach

The four "Yamanaka factors" have been known to induce pluripotency for some time. Forced expression of these four genes has been reported to turn an adult cell into what appears to be a pluripotent stem cell, with all that entails. However, this report illustrates that stem cell differentiation is a continuum.

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N of One: An Experiment In Not Flying Breathlessly

N of One: An Experiment In Not Flying Breathlessly

On a recent trip to California, my goal was to document an aircraft’s actual interior cabin altitude, versus the altitude of that aircraft’s distance above the ground. Finding this altitude would tell me how much oxygen would be in the cabin, where lower altitudes would mean more available oxygen.

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What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

Here is a fun question... Can you name one hole in your body that, if sewn shut, would help you function better?

Assuming you have an anatomically normal body, the answer is none. While saying that "bad plumbing" causes Alzheimer's Disease is an oversimplification, it is a great way to quickly explain why we angel invested in Leucadia Therapeutics in 2015. The Principal Scientist, Founder, and CEO of Leucadia Therapeutics, Doug Ethell, Ph.D., had an Occam Razor's approach to AD, which was refreshing to us and an inspiration. As it turns out, the Cribriform Plate that drains cerebrospinal fluid can get ossified or clogged as you age. In AD patients, it is always significantly clogged, thus the "bad plumbing" analogy. 


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Decades and Billions of Dollars Have Been Lost in the War Against Alzheimer's Disease

Decades and Billions of Dollars Have Been Lost in the War Against Alzheimer's Disease

At Methuselah Foundation we understand that the war against AD is one that humanity cannot afford to loose. We applaud revisiting the roadmap that will lead us to a cure. Writer John Carroll analyses this imperative in the Endpoints News article titled "After yet another PhIII Alzheimer’s failure, experts try to map a path out of the wrecking field."

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Reconsidering Alzheimer's Disease

Reconsidering Alzheimer's Disease

In light of the underwhelming efficacy of human anti-Abeta clinical trials in the last several years, we are pleased to read the scientific community starting to reconsider the theory that amyloid beta (Abeta) is the primary causative factor in Alzheimer's disease. This paper is among several we've seen over the past year which criticizes the amyloid cascade hypothesis, and does a good job of balancing the supportive and contradictory evidence for the hypothesis.

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A Day in the Life of a 90-Year-Old

A Day in the Life of a 90-Year-Old

The elderly have wisdom of great value to all, but few listen. Their story is worth being heard. If things don’t change, we will all share their experience. This first-person narrative is the result of years of interviews and the extensive experience of a Registered Nurse specializing in Geriatrics. We invite you to live a day in the live of a 90 year old.

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Mark Your Calendars: 2018 Senescence Research Meetings

Mark Your Calendars: 2018 Senescence Research Meetings

One of the best way to meet others in our community and stay current  is to attend several conventions and events hosted by institutions focused on Longevity. The following is a list of events in chronological order that will add to your knowledge base. Special thanks to John D. Furber for compiling this comprehensive list!

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Has Human Longevity Really Plateaued?

Has Human Longevity Really Plateaued?

Many in our community were distraught when a paper published in Nature not only said that the maximum human lifespan had plateaued but also set that maximum number to 115 years. Thankfully, many discerning scientists decided to spend their resources understanding the data, the claims, and drawing their own conclusions. In this article by Gizmodo writer Ryan F. Mandelbaum brings to the surfaces some issues found in the world of publishing research data.

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Does Older Age Result in Loss of Our Civil Rights?

Does Older Age Result in Loss of Our Civil Rights?

Independence: That is just one of the many reason for wanting to live longer, healthier lives. In practice, elderly citizens from the United States and other nations can become vulnerable to extortion, manipulations and victims of unscrupulous guardians. The New Yorker's October 9, 2017 Issue contained an eye-opening article written by Rachel Aviv and titled: "How the Elderly Lose Their Rights."

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