In light of the underwhelming efficacy of human anti-Abeta clinical trials in the last several years, we are pleased to read the scientific community starting to reconsider the theory that amyloid beta (Abeta) is the primary causative factor in Alzheimer's disease. This paper is among several we've seen over the past year which criticizes the amyloid cascade hypothesis, and does a good job of balancing the supportive and contradictory evidence for the hypothesis.