Researchers in Maryland recently conducted a test examining 3,600 different samples of bacteria from 1,165 healthy individuals age 20-90. They found that bacteria actually differs vastly between various age groups. They think this “microbiome aging clock” could be used as a baseline to test how fast or slow a person’s gut is aging and how different diets might have an effect on longevity.Read More
Intestinal worms have long caused suffering in humans, but has our bias against a handful of harmful helminths led us to slaughter billions of helpful ones? Is our quest as humans to eradicate parasitic worms being accomplished to our detriment? And if we could treat or even prevent many of our modern inflammatory diseases with harmless intestinal worms, why don’t we?Read More
Light exposure on the retina of the eye plays a critical role in entraining the circadian rhythm—the daily oscillation of tissue function, including the secretion of different hormones at different times.Read More
There are 3D bioprinters but no 3D printed usable organs. Why is that? Microvascularization is a key rate limiter preventing humans needing an organ transplant from having it made available to them. In other words, blood needs to get to the 3D printed tissue in order for the tissue to remain alive. Thankfully, a start-up we have proudly supported from inception is developing the necessary tools to solve the microvascularization challenge so that we can have functioning 3D printed organs.Read More
On a recent trip to California, my goal was to document an aircraft’s actual interior cabin altitude, versus the altitude of that aircraft’s distance above the ground. Finding this altitude would tell me how much oxygen would be in the cabin, where lower altitudes would mean more available oxygen.Read More
We modestly present a journey into our personal experience with "near field environmental factors" and health. This series will be the first entry in what we hope will become a shared resource that helps us all get better and better. Welcome to N of One!Read More
The elderly have wisdom of great value to all, but few listen. Their story is worth being heard. If things don’t change, we will all share their experience. This first-person narrative is the result of years of interviews and the extensive experience of a Registered Nurse specializing in Geriatrics. We invite you to live a day in the live of a 90 year old.Read More
The Methuselah Fund or M Fund is mission-oriented and was conceived after successful angel investments by the Methuselah Foundation. The M Fund's investment thesis is based on six strategies aimed at increasing healthy longevity and its current portfolio includes four exciting companies.Read More
For a while, we have seen that anti-aging is rapidly becoming an engineering challenge rather than a mere fantasy. To this point, our Foundation is also working on helping create a professional society focused on Geroengineering. Enter, the Society of Gero-Engineering and Technology, or SGET.Read More
Here is a fun question... Can you name one hole in your body that, if sewn shut, would help you function better?
Assuming you have an anatomically normal body, the answer is none. While saying that "bad plumbing" causes Alzheimer's Disease is an oversimplification, it is a great way to quickly explain why we angel invested in Leucadia Therapeutics in 2015. The Principal Scientist, Founder, and CEO of Leucadia Therapeutics, Doug Ethell, Ph.D., had an Occam Razor's approach to AD, which was refreshing to us and an inspiration. As it turns out, the Cribriform Plate that drains cerebrospinal fluid can get ossified or clogged as you age. In AD patients, it is always significantly clogged, thus the "bad plumbing" analogy.
In light of the underwhelming efficacy of human anti-Abeta clinical trials in the last several years, we are pleased to read the scientific community starting to reconsider the theory that amyloid beta (Abeta) is the primary causative factor in Alzheimer's disease. This paper is among several we've seen over the past year which criticizes the amyloid cascade hypothesis, and does a good job of balancing the supportive and contradictory evidence for the hypothesis.Read More
What's new at Methuselah Foundation? What recent scientific data has you excited about the future of this field? What should I do in order to be a healthier longer live? These are questions we received on an on-going basis. That is why we've decided to change our blog in a way that adds value to our community. We will mainly act as an aggregator of media, with some original pieces sprinkled in between. We hope that this new format will have you coming back for more content!Read More