What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

Here is a fun question... Can you name one hole in your body that, if sewn shut, would help you function better?

Assuming you have an anatomically normal body, the answer is none. While saying that "bad plumbing" causes Alzheimer's Disease is an oversimplification, it is a great way to quickly explain why we angel invested in Leucadia Therapeutics in 2015. The Principal Scientist, Founder, and CEO of Leucadia Therapeutics, Doug Ethell, Ph.D., had an Occam Razor's approach to AD, which was refreshing to us and an inspiration. As it turns out, the Cribriform Plate that drains cerebrospinal fluid can get ossified or clogged as you age. In AD patients, it is always significantly clogged, thus the "bad plumbing" analogy. 


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Decades and Billions of Dollars Have Been Lost in the War Against Alzheimer's Disease

Decades and Billions of Dollars Have Been Lost in the War Against Alzheimer's Disease

At Methuselah Foundation we understand that the war against AD is one that humanity cannot afford to loose. We applaud revisiting the roadmap that will lead us to a cure. Writer John Carroll analyses this imperative in the Endpoints News article titled "After yet another PhIII Alzheimer’s failure, experts try to map a path out of the wrecking field."

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Reconsidering Alzheimer's Disease

Reconsidering Alzheimer's Disease

In light of the underwhelming efficacy of human anti-Abeta clinical trials in the last several years, we are pleased to read the scientific community starting to reconsider the theory that amyloid beta (Abeta) is the primary causative factor in Alzheimer's disease. This paper is among several we've seen over the past year which criticizes the amyloid cascade hypothesis, and does a good job of balancing the supportive and contradictory evidence for the hypothesis.

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