Society for Gero-Engineering and Technology (SGET)

Society for Gero-Engineering and Technology (SGET)

For a while, we have seen that anti-aging is rapidly becoming an engineering challenge rather than a mere fantasy. To this point, our Foundation is also working on helping create a professional society focused on Geroengineering. Enter, the Society of Gero-Engineering and Technology, or SGET.

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Biological Age Estimation Methods: A Systematic Review

Biological Age Estimation Methods: A Systematic Review

Aging is a complicated process and is highly varied among individuals. We all have that friend who "doesn't look a day over 30" well into middle-age, and the less fortunate friend who isn't aging "gracefully". You may notice aging variability within your own body. Perhaps you have overall excellent health, but your digestion has slowed or you have sleep-pattern changes. Research shows that the quantity of years is a poor estimator as an index of the aging process. Even twins often have different biological or functional ages, and within an individual, organs may age at different rates. 

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The Gut Bacteria Is More Important Than You Think!

The Gut Bacteria Is More Important Than You Think!

For centuries, man has been attempting to extend the healthy human lifespan by investigating the correlation between health and the microbiome. In the past, these methods have been largely unsuccessful. New research is emerging that focuses on the 29 strains of E. coli that protect against age-associated diseases, causing the host to live at least 10% longer and healthier.

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Another Threat to Our Longevity: Chronic Dosing and Overprescribing

Another Threat to Our Longevity: Chronic Dosing and Overprescribing

What happens when the industry created to keep you alive pushes products that ultimately aid in your death? We are often concerned about incentives in the healthcare industry to prescribe medicine when it is not necessary and even when a simple lifestyle change would achieve the same beneficial effects.

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The Investment Scene for Longevity is Heating Up!

The Investment Scene for Longevity is Heating Up!

Over 10 years ago, we realized that investing in longevity companies has a two-fold benefit. Such investments accelerate products into the market that we all benefit from and also pours more capital into private research, resulting in breakthroughs in the longevity space. 

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Want To Reduce Your Senescent Cells? An Argument For Diet-Induced Weight Loss

Want To Reduce Your Senescent Cells? An Argument For Diet-Induced Weight Loss

Cellular senescence is an increasingly popular topic. Dysfunctional cells have been implicated in numerous age-related dysfunctions. While the efforts to remove these senile cells have been growing, this study shows that at least one form of cellular senescence can be addressed without drugs or other high-tech interventions.

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Understanding Cell Reprogramming: The Promising Cautious Approach

Understanding Cell Reprogramming: The Promising Cautious Approach

The four "Yamanaka factors" have been known to induce pluripotency for some time. Forced expression of these four genes has been reported to turn an adult cell into what appears to be a pluripotent stem cell, with all that entails. However, this report illustrates that stem cell differentiation is a continuum.

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What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

What If Alzheimer's Disease Is Caused by "Bad Plumbing"?

Here is a fun question... Can you name one hole in your body that, if sewn shut, would help you function better?

Assuming you have an anatomically normal body, the answer is none. While saying that "bad plumbing" causes Alzheimer's Disease is an oversimplification, it is a great way to quickly explain why we angel invested in Leucadia Therapeutics in 2015. The Principal Scientist, Founder, and CEO of Leucadia Therapeutics, Doug Ethell, Ph.D., had an Occam Razor's approach to AD, which was refreshing to us and an inspiration. As it turns out, the Cribriform Plate that drains cerebrospinal fluid can get ossified or clogged as you age. In AD patients, it is always significantly clogged, thus the "bad plumbing" analogy. 


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Decades and Billions of Dollars Have Been Lost in the War Against Alzheimer's Disease

Decades and Billions of Dollars Have Been Lost in the War Against Alzheimer's Disease

At Methuselah Foundation we understand that the war against AD is one that humanity cannot afford to loose. We applaud revisiting the roadmap that will lead us to a cure. Writer John Carroll analyses this imperative in the Endpoints News article titled "After yet another PhIII Alzheimer’s failure, experts try to map a path out of the wrecking field."

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Reconsidering Alzheimer's Disease

Reconsidering Alzheimer's Disease

In light of the underwhelming efficacy of human anti-Abeta clinical trials in the last several years, we are pleased to read the scientific community starting to reconsider the theory that amyloid beta (Abeta) is the primary causative factor in Alzheimer's disease. This paper is among several we've seen over the past year which criticizes the amyloid cascade hypothesis, and does a good job of balancing the supportive and contradictory evidence for the hypothesis.

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